Words similar to tnfr

Example sentences for: tnfr

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Interestingly, the three 20 mer HSPLs but not KcF12 were competed by an anti-TNFR2 monoclonal antibody, mAb226, (Figure 2) suggesting that KCF12 binds to a hotspot on TNFR2 distinct from the other 3 peptides.
APC = allophycocyanin; ARE = AU-rich element; CM = complete media; ELISA = enzyme-linked immunosorbent assay; FACS = fluorescence-activated cell sorting; FITC = fluorescein isothiocyanate; IL = interleukin; KLH = keyhole limpet hemocyanin; LPS = lipopolysaccharide; MESF = milliequivalents of soluble fluorescein; RPMI = Roswell Park Memorial Institute [medium]; RT-PCR = reverse transcriptase polymerase chain reaction; TNF = tumor necrosis factor; TNFR = TNF receptor; TTP = tristetraprolin; WBC = white blood cell.
TNFR1, TNFR2, TNF-α and TNF-β were obtained from R&D Systems (Minneapolis, MN) and reconstituted according to the manufacturer's instructions.
Closer examination of the complementary sequences revealed that the short N-terminal sequence RKEMG and the C-terminal sequence WSENLFQ were identical to regions on TNFR1 (amino acids 77-81 and 107-113 respectively).
Overall, these data indicate that the surface topology of the TNFR2 binding site is very complex and may be composed of multiple hotspots capable of different regulatory functions.