Words similar to tlr

Example sentences for: tlr

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Subsequently, overexpression of the wild-type Tlr4 protein was found to enhance LPS signal transduction in wild-type macrophages, lowering the effective concentration (EC 50 ) for LPS by a factor of 30, whereas overexpression of the Tlr4 Lps-disoform represented in C3H/HeJ mice almost completely suppresses signaling [ 12].
As mice of the C3H/HeJ strain are highly susceptible to infection by Gram-negative bacteria, it would seem plausible that among human patients with Gram-negative sepsis, some individuals may have been at risk by virtue of mutations in TLR4 . The first step in determining whether different isoforms of Tlr4 confer added risk of, or protection against, sepsis is the assessment of genetic variability at this locus in the normal population.
As such, the primary structure of a Tlr4 molecule determines ligand specificity [ 13], accounting for the well-known observation that mouse cells can recognize tetra-acyl lipid A as an agonist [ 20] whereas human cells recognize it as an antagonist [ 20, 21, 22, 23, 24].
Determination of the complete mouse ( Tlr4) and human ( TLR4) genomic sequences
The ancestry of different Tlr4 alleles can be traced by haplotype analysis, as many deviations from the reference allele occur in conjunction with one another.