Words similar to thromboxane
Example sentences for: thromboxane
How can you use “thromboxane” in a sentence? Here are some example sentences to help you improve your vocabulary:
COX = cyclooxygenase; HF = human fibroblasts; NL = normal lungs; IPF = idiopathic pulmonary fibrosis; IFN = interferon; IL = interleukin; PG = prostaglandin; TX = thromboxane; PGI 2 = prostacyclin.
Bernard et al . [ 10 ] reported that, in patients with sepsis, treatment with ibuprofen reduced levels of prostacylin and thromboxane and decreased fever, tachycardia, oxygen consumption, and lactic acidosis, but did not prevent the development of shock or acute respiratory distress syndrome, and did not improve survival.
Prostanoids are important regulators of fibroblast function [ 5 6 7 8 9 ] . Prostaglandin (PG)E 2 is thought to have antifibrotic properties in vitro , but also can have proinflammatory effects both in vivo and in vitro [ 10 11 12 ] . Thromboxane (TX)A 2 increases proliferation, and DNA and RNA synthesis in several cell types, including fibroblasts and smooth muscle like glomerular mesangial cells [ 13 14 15 16 ] . Conversely, prostacyclin (PGI 2 ) decreases smooth muscle cell proliferation and collagen synthesis [ 17 18 ] .
There was a greater than 50% reduction in PG D 2 production in clone 11 compared with the vector only control and a similar decrease in levels of PGs F 2α , 6keto-F 1α and thromboxane B 2 in this clone (Fig 7A).
We have found that fibroblasts cultured from normal and IPF human lungs have a significant and similar induction of the COX-2 enzyme when stimulated with IL-1β, but that IPF fibroblasts produced more thromboxane and had a significantly lower prostacyclin:thromboxane ratio.
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