Words similar to thrombophilia
Example sentences for: thrombophilia
How can you use “thrombophilia” in a sentence? Here are some example sentences to help you improve your vocabulary:
These include increased platelet activation, increased thrombin generation, and more recently, elevated levels of circulating tissue factor [ 14 ] . Over the past decade, mutations in a number of genes have been identified as the cause of thrombophilia in a large number of patients from different populations around the globe.
Formal evidence for this association came from a large population-based patient-control study, the Leiden Thrombophilia Study, which followed 474 consecutive patients of less than 70 years of age with a first episode of objectively confirmed DVT [ 9].
Thus, we propose to study polymorphisms in genes involved in a number of systems and pathways related to stroke risk [ 5 ] : genes associated with coagulation factors and thrombophilia (Factor V, Prothrombin, Fibrinogen, Factor VII, Factor XIII, PAI-1, Thrombomodulin [TM], and MTHFR), as well as polymorphisms in genes that are involved in vascular reactivity (ACE), platelet activation/function (GpIIb/IIIa, GpIb IX-V, and GpIa/IIa), endothelial cell function (MTHFR, TM, VCAM-1, E-Selectin, L-Selectin, P-Selectin, and ICAM-1), inflammation (TNFα), lipid metabolism (Apo A1 and Apo E), and cell adhesion (VCAM-1, E-Selectin, L-Selectin, P-Selectin, and ICAM-1).
The molecular basis of inherited thrombophilia now includes mutations in the genes for Factor V, prothrombin, methylenetetrahydrofolate reductase (MTHFR) and several others [ 15 ] , in addition to those encoding proteins such as antithrombin, protein C, and protein S whose role in the homeostasis between procoagulant and anticoagulant activities in the circulation is well established.
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