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Example sentences for: thrb
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Similarly, the distribution of D values for the comparison of the proteomic thrA and thrB sequences is also represented in Figure 4, alongside with the null model, Eq. 11, for its dimensionality ( n = log 2 ( uu = 20 possible aminoacids) = 4.32 ), which is graphically nearly undistiguishable from that of the comparison between the stanzas, with n = log 2 ( uu = 19 possible letters) = 4.25 (dotted gray line for the rounded value, n = 4.3).
The genomic sequences of thrA and thrB were translated into proteomic sequences using SwissProt's on line translator, applied to the 5'3' first frame http://www.expasy.ch/tools/dna.html.
For the analysis of this figure it is noteworthy to recall that the statistical properties of prokaryote DNA are often undistinguishable from uniform randomness [ 12 18 19 ] . The genomic sequence of the first gene of the threonine operon of E. coli, thrA, is compared with that of the second, thrB.
Our results confirm that the important changes are indeed associated with subunit B. We also point out that the RNA main chain passes near ThrB59, causing us to wonder whether some substitutions here create steric clashes, thus contributing to an RNA-binding defect by introducing an unfavorable contact.
In summary, we found that RNA binding activity tolerates substitution of ThrB45, but not of ThrA45.