Example sentences for: tgf-βs

How can you use “tgf-βs” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For example, tamoxifen resistance in a xenograft model of advanced human breast cancer, was recently shown [ 50] to be associated with an increase in TGF-βs and concomitant immunosuppressive effects on natural killer cells.

  • This staining pattern is consistent with a role for the TGF-βs in the maintenance of normal mammary homeostasis.

  • There is considerable evidence to suggest that, at late stages in tumorigenesis, TGF-βs can actually promote the tumorigenic process, particularly if the epithelial cells have lost responsiveness to the growth regulatory effects of TGF-β by this time [ 9, 39, 40, 41].

  • In this regard, this demonstration that the expression of TGF-βs in the preclinical rat model is unaffected by tamoxifen, 9cRA, or 4-HPR may actually have positive implications, because all three agents are already in clinical use.

  • They were present both in the ductal epithelium and in the periductal stroma, suggesting that the TGF-βs are synthesized by the epithelial cells, and possibly stromal cells, and are sequestered in the extracellular matrix.


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