Words similar to tetramer
Example sentences for: tetramer
How can you use “tetramer” in a sentence? Here are some example sentences to help you improve your vocabulary:
Lymphocytes were identified by forward and side scatter signals, then selected for CD8+ and tetramer positive.
The bacterial K +channel KcsA, whose X-ray crystal structure has been solved and is definitively a tetramer [ 30 ] , runs as a tetramer on SDS gels [ 31 ] . Furthermore, mutations that disrupt a known intersubunit interface at the level of the pore disrupt this biochemical tetramerization.
Their findings also bring into question the ability to deduce the recognition efficiency and tumor reactivity of T cell responses from ELISPOT and tetramer staining assays—the two standard measures of T cell responses to vaccines—which has implications for rational vaccine design in general.
Although staining with peptide–MHC tetramers provides a direct estimate for the number of TAA-specific T cells present in vivo, and intensity of tetramer staining has been employed as a parameter for isolation of high-RE, tumor-lytic T cells [27], staining intensity does not correlate well with RE or tumor-lytic potential [28,29], and cannot be considered a reliable indicator for the functional status of TAA-specific T cells.
For example, of the nine clones analyzed from patient 517, none were efficient in tumor cell lysis, yet these cells were detectable by MHC tetramer staining.