Words similar to tetramer
Example sentences for: tetramer
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Their findings also bring into question the ability to deduce the recognition efficiency and tumor reactivity of T cell responses from ELISPOT and tetramer staining assays—the two standard measures of T cell responses to vaccines—which has implications for rational vaccine design in general.
Analysis of the crystal structure of GlpF suggests that potential ion binding sites may be located in the central pore, at the four-fold axis of symmetry in the tetrameric association of subunits that form the channel [ 15 ] . Interestingly, this arrangement of a tetramer of subunits to form a central ion pore is a hallmark of the family of voltage-gated ion channels [ 23 ] , which rely on a tetrameric organization to create a central pore for ions that is lined by sequences contributed from all four subunits.
Since the knowledge of the Mamu-A*01-restricted epitopes [ 32][ 33] allows for a quantitation of the CD8+ T-cell response using the tetramer technology [ 34], Mamu-A*01 macaques were chosen for this study.
Although staining with peptide–MHC tetramers provides a direct estimate for the number of TAA-specific T cells present in vivo, and intensity of tetramer staining has been employed as a parameter for isolation of high-RE, tumor-lytic T cells [27], staining intensity does not correlate well with RE or tumor-lytic potential [28,29], and cannot be considered a reliable indicator for the functional status of TAA-specific T cells.
In recent cancer vaccine trials [3,4,5], many melanoma patients who received heteroclitic peptide vaccines gp100 209–217 (210M) (IMDQVPSFV; G209–2M) and MART 26–35 (27L) (ELAGIGILTV; M26) had measurable CD8+ peptide-specific T cell responses in PBMCs detected by peptide–MHC tetramer staining.
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