Words similar to terminus
Example sentences for: terminus
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This region can, by itself, activate transcription when targeted to the DNA via a heterologous DNA-binding domain [ 5 ] . On the other hand, the LRR plus C-terminal region of yCCR4 cannot mediate transcription activation, but is involved in protein-protein interactions [ 5 ] . The yCCR4 LRR is necessary for the binding of several components of the CCR4-NOT complex, including yPOP2 -and mCAF1- [ 11 ] , yDBF2 [ 2 ] , yCAF4 and yCAF16 [ 8 ] , and deletion of the yCCR4 N-terminus does not impair these associations.
Its core contains 5 conserved strands, followed, at the extreme C-terminus, by a long helix that is likely to form a coiled-coil linker region involved in dimerization (Fig.
Although chromatid breakage requires an endonuclease activity, the cutter, directed by a Cbs-binding activity, no Cbs-dependent "binder/cutter" activity has been detected in vitro . The cutter could be an activity of telomerase itself [ 39 43 ] . Telomerase of both Tetrahymena and Euplotes has a single-strand endonuclease activity [ 45 43 ] . It can trim potential primers back, so that the 3' terminus pairs with template RNA [ 46 ] . Thus, while it may serve a 3' editing function, the existence of a nuclease activity in potential proximity to the site of chromatid breakage is provocative, suggesting that telomerase provides the
This modification occurs on a cysteine residue, three residues proximal to the C-terminus with two aliphatic amino acids separating the cysteine from the C-terminus (hence the term CAAX box).
The PIPs were observed to have two different amino-terminal extensions, one approximately 50, the second approximately 30 amino-acid residues longer than the AQPs with the shortest amino terminus (SIP1;2, SIP2;1).
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