Words similar to surfactant-associated

Example sentences for: surfactant-associated

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Surfactant, a lipoprotein comprised of phospholipids (~80%), cholesterol (~10%), and proteins (~10%), functions to reduce surface tension and prevents alveolar collapse at end expiration [ 4 ] . The surfactant-associated proteins (SP) A, B, C and D, which are required for proper surfactant function, are developmentally and hormonally regulated [ 4 ] . We, and others, have shown that the SP-A levels in the amniotic fluid of diabetic mothers are significantly decreased [ 1 ] . Low SP-A levels in amniotic fluid have been correlated with an increased incidence of neonatal RDS [ 5 ] . Our previous studies have shown that insulin down-regulates SP-A mRNA and protein levels in human lung epithelial cells in a concentration and time-dependent manner via an inhibition of gene transcription [ 6 7 ] .