Words similar to surfactant
Example sentences for: surfactant
How can you use “surfactant” in a sentence? Here are some example sentences to help you improve your vocabulary:
Fetuses of diabetic mothers with uncontrolled blood glucose levels tend to be hyperglycemic and hyperinsulinemic [ 1 ] . An increased incidence of neonatal respiratory distress syndrome (RDS) has been observed in infants of diabetic mothers [ 1 ] . RDS is caused by inadequate amounts of pulmonary surfactant due to delayed lung development [ 2 ] . It has been proposed that high insulin levels can delay lung development in the fetus of the diabetic mother [ 3 ] .
A 202-bp portion corresponding to nucleotides 441 to 643 of the rat surfactant protein B gene (emb|X14778|RNSPB) [ 38] was amplified from rat lung RNA by RT-PCR and then cloned as follows.
Cloning of a rat surfactant protein B gene fragment
Our findings further characterize the signal transduction pathways that control surfactant protein gene expression.
Surfactant, a lipoprotein comprised of phospholipids (~80%), cholesterol (~10%), and proteins (~10%), functions to reduce surface tension and prevents alveolar collapse at end expiration [ 4 ] . The surfactant-associated proteins (SP) A, B, C and D, which are required for proper surfactant function, are developmentally and hormonally regulated [ 4 ] . We, and others, have shown that the SP-A levels in the amniotic fluid of diabetic mothers are significantly decreased [ 1 ] . Low SP-A levels in amniotic fluid have been correlated with an increased incidence of neonatal RDS [ 5 ] . Our previous studies have shown that insulin down-regulates SP-A mRNA and protein levels in human lung epithelial cells in a concentration and time-dependent manner via an inhibition of gene transcription [ 6 7 ] .
Loading...