Words similar to subcomplexes
Example sentences for: subcomplexes
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Finally, the encoded proteins are associated with distinct NPC subcomplexes [ 2 ] , and we speculated that true mislocalization mutants would require disruption of both sets of subcomplexes and more likely reflect defects in global NPC structure and assembly.
Mutants perturbing GFP-Nup localization could include cells with 1) NPC clusters in NE subregions, 2) mislocalization of the GFP-Nup or aggregated NPC subcomplexes to the cytoplasm or nucleus (due to either a block in new assembly or increased instability of existing NPCs), 3) mislocalization of the GFP-Nup due to indirect perturbation of the ER and NE membrane, or 4) decreased GFP-Nup incorporation followed by turnover resulting in cells with diminished total fluorescence.
Experiments using immuno-fluorescence in vertebrate cells are beginning to order the recruitment and timing of incorporation of individual nucleoporins during post-mitotic re-assembly [ 12 13 14 15 ] . Additionally, in vitro assembly studies with Xenopus egg or mitotic cell extracts have revealed several intermediates in NPC assembly and demonstrated a requirement for an intact double nuclear membrane prior to post-mitotic NPC assembly [ 16 17 18 19 ] . The modular nature of the NPC structure has also suggested that subcomplexes of discrete Nups may initially form and provide building blocks for biogenesis.
It thus appears that part of the diversification of CSN function may arise from formation of smaller subcomplexes.
NIC96 is an essential nucleoporin and a member of multiple biochemically distinct NPC subcomplexes [ 29 30 ] . NUP170 , while not essential, is physically and genetically linked to a distinct subset of nucleoporins [ 31 32 33 34 ] . The rationale for using NIC96 and NUP170 are several-fold.
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