Words similar to sterile
Example sentences for: sterile
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The proto-oncogene TEL (Translocation, Ets, Leukemia) is a transcriptional repressor that contains a C-terminal Ets family DNA binding domain; a central domain that together with co-repressors recruit histone deacetylases [ 1 2 3 ] ; and an N-terminal SAM (sterile, alpha, motif) domain [ 4 5 6 ] , which we have recently shown forms a polymer [ 7 ] . Chromosomal translocations in a variety of leukemias result in fusion of the SAM domain of TEL to tyrosine kinase domains such as ABL, PDGFβ and JAK2 [ 8 9 10 11 12 13 14 ] or to the transcriptional activators AML1 and ARNT [ 15 16 17 ] . In the tyrosine kinase fusions, SAM domain polymerization leads to constitutive activation of the tyrosine kinase domains, which leads in turn to cell transformation [ 10 12 18 19 ] . Thus, compounds that block TEL-SAM polymerization could be effective in treating these leukemias.
Sequences expressed in pure, axenic cultures from P. sojae mycelia and zoospores [ 18] and from sterile, uninoculated M. truncatula roots [ 6] provided a basis for comparison in which no foreign transcripts were expected.
Is it a sterile slave, under control?
Conceptuses were flushed into a sterile petri dish from the uterine horn and evaluated to determine an appropriate time-delayed removal of the second horn corresponding to the predicted time conceptuses would be in a tubular morphology as described by Geisert et al.
The sterile soil, after heat treatment, did not yield significant amounts of our targeted redox signature molecules: nicotinamide, riboflavin, Q 0 , FMN, FAD, and porphyrin (Figure 1).
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