Words similar to sterically
Example sentences for: sterically
How can you use “sterically” in a sentence? Here are some example sentences to help you improve your vocabulary:
The second alternative cause for our failure to detect RNAseH activity is that the RNAseH active site may be sterically blocked in core particles.
Site b 1 must consequently be filled with a Chl a molecule [ 38 ] . The orientation of the transition moments of Chl b in sites b 5 and b 6 [ 38 ] suggest that an 'out-lying' Chl a molecule could coordinate with the formyl group of Chl b, a sterically more favorable arrangement than coordination to the 13 1-carbonyl oxygen because of the opposing orientations of the 13 2-carboxymethyl and 17-propionyl group (Fig.
Alternatively, recruitment of another protein to the mammalian COP1 RING finger may sterically hinder access of its NLS to the nuclear import machinery.
A search in the database of known protein structures employing the 'loop-search' algorithm of SYBYL yielded 100 loops, of which only five were sterically permissible.
Two molecular loci recently have been implicated as potential modulators of GnRH receptor signaling: one is the receptor itself [ 23 ] , and the other is the G protein that transduces the signal generated by binding of the receptor to its agonist [ 9 ] . With respect to the former locus, G protein coupled receptor kinases (GRKs) act in an agonist-specific manner to phosphorylate intracellular regions of the receptor thus permitting β arrestin binding that sterically inhibits G protein association with the receptor [ 1 45 ] . We have reported previously that experimental expression of GRKs in GnRH receptor-expressing heterologous cells (COS-1) suppressed GnRH-stimulated IP 3 production, and that co-expression of GRK2 and β-arrestin 2 suppressed GnRH receptor signaling more than that of either alone [ 23 ] . Stronger evidence that the GRK/β arrestin paradigm may play a role in regulating GnRH receptor signaling is our recent finding that adenovirus-mediated gene transfer of GRK2 into normal pituitary gonadotropes suppressed GnRH-stimulated LH secretion and IP 3 production [ 31 ] . However, no evidence has been presented for a direct interaction between β-arrestin and the GnRH receptor.
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