Words similar to spliceosome
Example sentences for: spliceosome
How can you use “spliceosome” in a sentence? Here are some example sentences to help you improve your vocabulary:
Our data suggests that nmt55/p54 nrbmay be critical to cell growth and function, such that, decreased nmt55/p54 nrbexpression in ER- human breast tumors or the expression of nmt55/p54 nrbvariants in ER+ tumors may indicate loss of normal growth, nmt55/p54 nrbhas been shown in several studies to bind RNA and interact with PSF and Topoisomerase I [ 14 16 17 18 19 20 39 ] . Those results along with our observations that nmt55/p54 nrbassociates with several splicing factors essential for spliceosome formation (unpublished) and relates to tumor hormonal status [ 13 ] suggest that nmt55/p54 nrbmay be involved in pre-mRNA processing.
Furthermore, exon sequences, outside of the proto-splice site, may be required for splice site recognition by the spliceosome [ 34 35 36 37 38 ] . Our rRNA analyses suggest that G-rich regions in the neighborhood (often upstream) of the intron insertion sites may be potential ESEs.
An information analysis was done of the 50 nt upstream and downstream of the different rRNA spliceosomal intron sites to determine the total amount of exonic information (in "bits") that is available to the spliceosome for splicing.
Splicing is carried out by the spliceosome, a large complex consisting of proteins and small nuclear RNAs (snRNAs) [ 1 2 3 ] . RNA splicing is dependent upon the identity of nucleotide sequences at the exon/intron boundaries.
Our studies on nmt55 and those of p54 nrbhave characterized this protein as an RNA binding protein with the ability to associate with Topoisomerase I and the polypyrimidine tract-binding protein associated splicing factor (PSF) [ 16 17 18 19 20 ] . Further, we observed the association of nmt55/p54 nrbwith several splicing factors known to be essential for spliceosome formation suggesting a role for nmt55/p54 nrbin pre-mRNA splicing (unpublished results).
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