Words similar to sphingomyelin

Example sentences for: sphingomyelin

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Sphingomyelin content and luteal cell membrane fluidity decrease during luteolysis in vivo [ 48 49 50 51 ] . Ceramide, a product of sphingomyelin hydrolysis, is a potent stress-activated second messenger and is well established as a functional component of death receptor-mediated apoptosis [ 52 53 54 ] . Upon treatment of CLENDO cells with TNFα, we observed a rapid and sustained increase in the production of ceramide, suggesting that the sphingomyelin pathway is present and active in these cells.
The ratios of 24:0/22:0 in sphingomyelin and PS/PI, 24:1n9/22:1n9 in PS/PI and CL, 22:4n6/20:4n6 in PC, PE, and CL, and 22:5n3/20:5n3 in PC and PE, were all reduced by FISH, whereas FUNG had either a neutral effect or partly reversed effects seen with FISH (with exception of CL 24:1n9/22:1n9 ratio).
The ratio of 18:1n7/16:1n7 in sphingomyelin was decreased by FUNG and FUNG+FISH; in PC, PE, and CL only FUNG feeding decreased the 18:1n7/16:1n7 ratio.
TNFα elevates ceramide in CLENDO cells, whereas sFasL elevates ceramide in primary luteal steroidogenic cells [ 26 ] . Ceramide treatment induces apoptosis in both cell types, suggesting that the sphingomyelin pathway may be a common mediator of cell death among distinct cell types within the CL.
Interestingly, we find that two different cytokines ( i.e. sFasL and TNFα) can activate the sphingomyelin pathway in two distinct CL cell types.