Words similar to sphingomyelin

Example sentences for: sphingomyelin

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Interestingly it has been demonstrated that rapid production of ROS in endothelial cells exposed to TNFα is mediated by ceramide [ 32 ] . Ceramide is a central figure in the sphingomyelin pathway, which has also been linked to stress related signaling and apoptosis [ 33 34 ] . This report provides evidence that cytokines regulate the fate of CLENDO cells.
TNFα elevates ceramide in CLENDO cells, whereas sFasL elevates ceramide in primary luteal steroidogenic cells [ 26 ] . Ceramide treatment induces apoptosis in both cell types, suggesting that the sphingomyelin pathway may be a common mediator of cell death among distinct cell types within the CL.
Interestingly, we find that two different cytokines ( i.e. sFasL and TNFα) can activate the sphingomyelin pathway in two distinct CL cell types.
Members of the DNase 1, LINE-1 repeats, inositol 5'-polyphosphate phosphatase, Nocturnin, CCR4, cytolethal distending toxin, neutral sphingomyelin phosphodiesterase, and amino acid methyltransferase families were found with expectation values of 10 -4or less to be significantly similar to APE1.
The ratios of 24:0/22:0 in sphingomyelin and PS/PI, 24:1n9/22:1n9 in PS/PI and CL, 22:4n6/20:4n6 in PC, PE, and CL, and 22:5n3/20:5n3 in PC and PE, were all reduced by FISH, whereas FUNG had either a neutral effect or partly reversed effects seen with FISH (with exception of CL 24:1n9/22:1n9 ratio).