Words similar to speb
Example sentences for: speb
How can you use “speb” in a sentence? Here are some example sentences to help you improve your vocabulary:
Organisms selected in this model are consistently negative for SpeB secretion.
Selection of SpeB negative variants have also been noted following sequential human blood passage of isolates or in a mouse skin infection model [ 39 41 ] . This selective pressure can also be associated with enhanced capsular expression in SpeB negative variants [ 42 ] .
This kidney-recovered variant restored SLS activity, and M and M-related protein expression but not SpeB or streptokinase (SK) secretion.
Previous studies from our laboratory have consistently demonstrated loss of the SpeB phenotype in S. pyogenes isolates injected in a skin air sac and recovered from the organs of lethally infected mice [ 10 16 ] . This selection was not associated with loss of β-hemolysis but was associated with over-expression of M and M-related proteins, which in turn are predictive of the invasive potential of the organism in a skin infection model [ 16 ] . Based on the phenotypic characteristics of the kidney-recovered variant (β-hemolytic positive, M and M-related protein positive and SpeB negative) we predicted that this variant would be as virulent or more virulent than the wild type organism in the mouse skin infection model.
Inactivation of the sagA/pel locus by insertion of a Tn 917 transposon into the promoter region leads to decreased expression of SLS, SpeB, SK as well as M and M-related proteins [ 4 ] and reduced virulence in a mouse model of infection using Cytodex beads [ 3 ] . In this paper we have shown that this mutation also leads to decreased or delayed virulence in a mouse air-sac model of infection.
Loading...