Words similar to speb
Example sentences for: speb
How can you use “speb” in a sentence? Here are some example sentences to help you improve your vocabulary:
Organisms selected in this model are consistently negative for SpeB secretion.
Previous studies have demonstrated that the inactivation of the sagA/pel gene product also effects expression of other key streptococcal products, including surface M proteins, streptokinase (SK) and the secreted cysteine protease, SpeB [ 4 ] . Analysis of SpeB, SK and M and M-related proteins was conducted to determine if restoration of the expression of the large sagA/pel transcript also reverted the other phenotypes associated with the wild type organism.
The sagA/pel mutant of isolate CS101 fails to express β-hemolysin, SpeB, SK or surface M and M-related proteins [ 4 ] . Based on prior studies from our laboratory [ 9 10 ] , we predicted that this isolate would be avirulent in the mouse skin air sac model.
This kidney-recovered variant restored SLS activity, and M and M-related protein expression but not SpeB or streptokinase (SK) secretion.
Previous studies from our laboratory have consistently demonstrated loss of the SpeB phenotype in S. pyogenes isolates injected in a skin air sac and recovered from the organs of lethally infected mice [ 10 16 ] . This selection was not associated with loss of β-hemolysis but was associated with over-expression of M and M-related proteins, which in turn are predictive of the invasive potential of the organism in a skin infection model [ 16 ] . Based on the phenotypic characteristics of the kidney-recovered variant (β-hemolytic positive, M and M-related protein positive and SpeB negative) we predicted that this variant would be as virulent or more virulent than the wild type organism in the mouse skin infection model.
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