Example sentences for: speb

How can you use “speb” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The sagA/pel mutant of isolate CS101 fails to express β-hemolysin, SpeB, SK or surface M and M-related proteins [ 4 ] . Based on prior studies from our laboratory [ 9 10 ] , we predicted that this isolate would be avirulent in the mouse skin air sac model.

  • The results present in figure 5indicate that the kidney-recovered variant was significantly more virulent than the sagA/pel mutant from which it was originally selected (p = 0.018) despite not secreting SpeB or SK in culture (see Table 2).

  • Inactivation of the sagA/pel locus by insertion of a Tn 917 transposon into the promoter region leads to decreased expression of SLS, SpeB, SK as well as M and M-related proteins [ 4 ] and reduced virulence in a mouse model of infection using Cytodex beads [ 3 ] . In this paper we have shown that this mutation also leads to decreased or delayed virulence in a mouse air-sac model of infection.

  • Organisms selected in this model are consistently negative for SpeB secretion.

  • The mouse selection process results not only in the restoration of a β-hemolytic positive phenotype, but also restored some, but not all, of the phenotypes known to be regulated by sagA/pel [ 4 ] . For example, fibrinogen-binding M and M-related protein expression was restored; however secretion of the cysteine protease, SpeB, or SK was not.


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