Words similar to speb
Example sentences for: speb
How can you use “speb” in a sentence? Here are some example sentences to help you improve your vocabulary:
Organisms selected in this model are consistently negative for SpeB secretion.
Previous studies have demonstrated that the inactivation of the sagA/pel gene product also effects expression of other key streptococcal products, including surface M proteins, streptokinase (SK) and the secreted cysteine protease, SpeB [ 4 ] . Analysis of SpeB, SK and M and M-related proteins was conducted to determine if restoration of the expression of the large sagA/pel transcript also reverted the other phenotypes associated with the wild type organism.
The mouse selection process results not only in the restoration of a β-hemolytic positive phenotype, but also restored some, but not all, of the phenotypes known to be regulated by sagA/pel [ 4 ] . For example, fibrinogen-binding M and M-related protein expression was restored; however secretion of the cysteine protease, SpeB, or SK was not.
Analysis of culture supernatants for the presence of SpeB (Fig.
Previous studies from our laboratory have consistently demonstrated loss of the SpeB phenotype in S. pyogenes isolates injected in a skin air sac and recovered from the organs of lethally infected mice [ 10 16 ] . This selection was not associated with loss of β-hemolysis but was associated with over-expression of M and M-related proteins, which in turn are predictive of the invasive potential of the organism in a skin infection model [ 16 ] . Based on the phenotypic characteristics of the kidney-recovered variant (β-hemolytic positive, M and M-related protein positive and SpeB negative) we predicted that this variant would be as virulent or more virulent than the wild type organism in the mouse skin infection model.
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