Example sentences for: speb

How can you use “speb” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The results present in figure 5indicate that the kidney-recovered variant was significantly more virulent than the sagA/pel mutant from which it was originally selected (p = 0.018) despite not secreting SpeB or SK in culture (see Table 2).

  • This kidney-recovered variant restored SLS activity, and M and M-related protein expression but not SpeB or streptokinase (SK) secretion.

  • Inactivation of the sagA/pel locus by insertion of a Tn 917 transposon into the promoter region leads to decreased expression of SLS, SpeB, SK as well as M and M-related proteins [ 4 ] and reduced virulence in a mouse model of infection using Cytodex beads [ 3 ] . In this paper we have shown that this mutation also leads to decreased or delayed virulence in a mouse air-sac model of infection.

  • Previous studies have demonstrated that the inactivation of the sagA/pel gene product also effects expression of other key streptococcal products, including surface M proteins, streptokinase (SK) and the secreted cysteine protease, SpeB [ 4 ] . Analysis of SpeB, SK and M and M-related proteins was conducted to determine if restoration of the expression of the large sagA/pel transcript also reverted the other phenotypes associated with the wild type organism.

  • The sagA/pel mutant of isolate CS101 fails to express β-hemolysin, SpeB, SK or surface M and M-related proteins [ 4 ] . Based on prior studies from our laboratory [ 9 10 ] , we predicted that this isolate would be avirulent in the mouse skin air sac model.


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