Example sentences for: sparc

How can you use “sparc” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Although SPARC has been postulated to be involved in wound healing due to its elevated expression in fibroblasts and macrophages at wound sites [ 18 ] , our results are the first to demonstrate that SPARC indeed plays a role in wound repair and that it does so by promoting granulation tissue formation through modulation of fibroblast migration.

  • SPARC can increase endothelial permeability and is known to participate in tumor angiogenesis and extravasation [ 17].

  • However, since SPARC is a matricellular protein involved in cell-matrix interaction [ 3 4 23 ] , cell-matrix interaction-related defects may exert a significant influence in large wounds of SPARC-null mice causing premature loss of a part of the scabs and of the neoepidermis, a pathophysiological process requiring repeated healing.

  • The mechanism by which SPARC influences cell migration is not known.

  • Monolayers were wounded using a 1 ml plastic micropipette tip and incubated at 37°C in DMEM containing 10% FBS or in DMEM containing 10% FBS and SPARC protein purified from human platelets (48 μg/ml; Calbiochem, La Jolla, CA).


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