Words similar to sparc
Example sentences for: sparc
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SPARC has been postulated to modulate cell shape [ 3 4 ] and cell adhesions [ 4 7 8 ] , to regulate cell proliferation [ 3 4 ] and migration [ 9 10 ] , and to influence matrix contraction [ 11 ] . In addition, SPARC is known to bind to certain growth factors [ 12 ] and to modulate expression of ECM components [ 13 ] . Many of these functions are requisite to wound repair.
Mesangial cells, adult skin fibroblasts and smooth muscle cells from SPARC-null mice proliferate faster than their respective wild-type counterparts in media containing fetal bovine serum (FBS) [ 17 ] . Although embryonic fibroblasts from the SPARC-null mice grow at the same rate as the wild-type cells when they are cultured in FBS, the SPARC-null embryonic fibroblasts exhibit down-regulated proliferation as compared to the wild-type cells when the fibroblasts are cultured in serum-free medium containing insulin as the sole mitogenic factor [ 16 ] . Thus, it appears that the role of SPARC in cell proliferation is cell type and environment dependent.
One possibility is that the lack of SPARC causes alteration in ECM with respect to structure and/or function and thus contributes to a decrease in cell migration.
Although SPARC is required for migration of dermal fibroblasts into the wound site, it is apparently not essential to the motility of keratinocytes since reepithelialization appears normal in SPARC-null mice.
The delay in granulation tissue formation and healing of excision wounds in SPARC-null mice, and the defect in wound closure in in vitro assays indicate that SPARC plays a role in wound healing through its effect on cell migration.
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