Words similar to sparc

Example sentences for: sparc

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Furthermore these defects were reversed by the addition of purified SPARC, showing that the defect in cell migration and wound healing was attributable to the absence of SPARC.
DMEM, Dulbecco's modified Eagle's medium; ECM, extracellular matrix; FBS, fetal bovine serum; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; PBS, phosphate buffered saline; SPARC, secreted protein acidic and rich in cysteine, also known as osteonectin and BM-40; SD, standard deviation.
SPARC has been postulated to modulate cell shape [ 3 4 ] and cell adhesions [ 4 7 8 ] , to regulate cell proliferation [ 3 4 ] and migration [ 9 10 ] , and to influence matrix contraction [ 11 ] . In addition, SPARC is known to bind to certain growth factors [ 12 ] and to modulate expression of ECM components [ 13 ] . Many of these functions are requisite to wound repair.
SPARC can increase endothelial permeability and is known to participate in tumor angiogenesis and extravasation [ 17].
In the absence of SPARC, expression of transforming growth factor-β1 and type I collagen is down-regulated in kidney mesangial cells [ 15 ] . The expression of cell surface receptor for insulin-like growth factor I in SPARC-null embryonic fibroblasts is also diminished [ 16 ] . Studies with SPARC-null cells have confirmed that SPARC functions in cell proliferation.