Words similar to sparc

Example sentences for: sparc

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Thus, the role of SPARC in cell migration may be cell type-specific, which has been shown to be the case with in vitro studies [ 7 9 10 ] . Cell motility is controlled by a cycle of cell attachment and detachment.
This defect in cell motility was rescued to the level of wild-type cells by the addition of purified SPARC (Fig.
The denuded area was repopulated by the SPARC-null cells by 11 hours in the presence of added SPARC (Fig.
Mesangial cells, adult skin fibroblasts and smooth muscle cells from SPARC-null mice proliferate faster than their respective wild-type counterparts in media containing fetal bovine serum (FBS) [ 17 ] . Although embryonic fibroblasts from the SPARC-null mice grow at the same rate as the wild-type cells when they are cultured in FBS, the SPARC-null embryonic fibroblasts exhibit down-regulated proliferation as compared to the wild-type cells when the fibroblasts are cultured in serum-free medium containing insulin as the sole mitogenic factor [ 16 ] . Thus, it appears that the role of SPARC in cell proliferation is cell type and environment dependent.
Monolayers were wounded using a 1 ml plastic micropipette tip and incubated at 37°C in DMEM containing 10% FBS or in DMEM containing 10% FBS and SPARC protein purified from human platelets (48 μg/ml; Calbiochem, La Jolla, CA).