Words similar to sparc
Example sentences for: sparc
How can you use “sparc” in a sentence? Here are some example sentences to help you improve your vocabulary:
This example illustrates how functional relationships that could not be deduced from gene names were uncovered through the analysis of patterns of term occurrence: matrix metalloproteinases (MMP1, 10, 14) and urokinase plasminogen activator (UPA, SPARC) are matrix-interacting molecules involved in tumor invasion and metastasis.
SPARC can increase endothelial permeability and is known to participate in tumor angiogenesis and extravasation [ 17].
Two independent experiments with 25 mm oblong full-thickness excision wounds (6 mice of each type per experiment), including the striated muscle layer (panniculus carnosus), on the dorsal skin of wild-type and SPARC-null mice indicated that the absence of SPARC impeded healing of skin wounds.
Previously, studies of phenotypes in this laboratory have shown that SPARC-null mice develop osteopenia around 2.5 months of age [ 19 ] in bones where SPARC is normally the most abundant non-collagenous glycoprotein [ 3 ] . The second phenotype thus far uncovered is in the lens where SPARC is normally produced by lens epithelial cells [ 20 21 ] and is a component of the lens capsule [ 20 22 ] . SPARC-null mice show progressive cataract formation beginning approximately 1.5 months after birth [ 14 21 ] . Electron microscopy of the SPARC-null lens revealed abnormality at the lens cell-ECM (capsule) interface with an intrusion of cellular processes into the basement membrane of the lens capsule, whereas wild-type lens exhibited a precise border at the cell-matrix interface [ 23 ] . In the present study, we show for the first time that SPARC plays a role in wound repair in vivo and in vitro.
To further test our conclusion, we investigated whether cell proliferation was affected by the lack of SPARC.
Loading...