Words similar to sparc-null
Example sentences for: sparc-null
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Primary dermal fibroblasts from SPARC-null mice contracted type I collagen gels as efficiently as primary dermal fibroblasts from wild-type mice, contracting to 30% of the initial area at 20 hours and to 15% by 40 hours after incubation of the fibroblasts in collagen gels (Fig.
Healing of SPARC-null wounds remained incomplete on day 24, and complete healing in all mice was observed between 25 and 31 days (Fig.
These results confirm that cell migration is a key step affecting the rate of wound healing and that this process is impaired in SPARC-null cells.
At day 6, reepithelialization and granulation tissue formation appeared as elaborate in SPARC-null mice as in wild-type mice with the neoepidermis and granulation tissue filling two third of the wound beds (not shown).
At day 2, the levels of the two transcripts decreased appreciably below the levels of the control skin followed by an increase in expression between day 2 and day 4. In the case of SPARC-null mice, expression of the two transcripts remained below the control unwounded skin at day 2 and day 4 and did not begin to increase until between day 4 and day 6 (Fig.