Words similar to sparc-null
Example sentences for: sparc-null
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Northern analysis of 6 mm circular wound tissues isolated during a 6 day healing period showed similar patterns of cytokeratin 14 expression in SPARC-null mice and wild-type mice (Fig.
Wild-type and SPARC-null dermal fibroblasts were plated in 96-well plates (1 × 10 4cells/well) and cultured overnight in DMEM containing 10% FBS.
Although the long period of impeded ingrowth of SPARC-null cells after wounding already suggested defect in cell migration rather than cell proliferation, we determined cell migration in the absence of cell proliferation.
We found that SPARC-null fibroblasts incorporated 3H-thymidine as efficiently as control wild-type fibroblasts over the 25 hour period studied (Fig.
It is generally accepted that the driving force for cell movement is provided by the dynamic reorganization of the actin cytoskeleton, directing protrusion (lamellipodia and filopodia) at the front of the cell and retraction at the rear [ 30 31 ] . Although we have not examined the ultrastructure of the dermal fibroblasts at the edge of wound sites, we showed previously by electron microscopy that in the lens of SPARC-null mice numerous cellular processes extended into the ECM of the lens capsule [ 23 ] . We further showed that, in contrast to the abnormal filopodial projections at the lens cell-ECM interface, cell-cell contacts between the neighboring lens epithelial cells and between the lens epithelial and fiber cells were normal [ 23 ] . The results indicate that disassembly of cell-cell contacts between lens cells is not taking place, despite the forward movement of the lens cells into the ECM of the capsule.
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