Words similar to sparc-null

Example sentences for: sparc-null

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Previously, studies of phenotypes in this laboratory have shown that SPARC-null mice develop osteopenia around 2.5 months of age [ 19 ] in bones where SPARC is normally the most abundant non-collagenous glycoprotein [ 3 ] . The second phenotype thus far uncovered is in the lens where SPARC is normally produced by lens epithelial cells [ 20 21 ] and is a component of the lens capsule [ 20 22 ] . SPARC-null mice show progressive cataract formation beginning approximately 1.5 months after birth [ 14 21 ] . Electron microscopy of the SPARC-null lens revealed abnormality at the lens cell-ECM (capsule) interface with an intrusion of cellular processes into the basement membrane of the lens capsule, whereas wild-type lens exhibited a precise border at the cell-matrix interface [ 23 ] . In the present study, we show for the first time that SPARC plays a role in wound repair in vivo and in vitro.
The delay in granulation tissue formation and healing of excision wounds in SPARC-null mice, and the defect in wound closure in in vitro assays indicate that SPARC plays a role in wound healing through its effect on cell migration.
Impaired wound repair by cultured SPARC-null fibroblasts
Wild-type and SPARC-null dermal fibroblasts were plated in 96-well plates (1 × 10 4cells/well) and cultured overnight in DMEM containing 10% FBS.
One day after surgery a clear thin film of dried exudate covered the wounds in the wild-type and SPARC-null mice.