Words similar to sparc-null
Example sentences for: sparc-null
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Wild-type and SPARC-null dermal fibroblasts were plated in 96-well plates (1 × 10 4cells/well) and cultured overnight in DMEM containing 10% FBS.
Furthermore, histological examination of new epidermal cells in the wound bed and Northern analysis of expression of a wound keratinocyte marker, cytokeratin 14, in the biopsied tissues revealed that reepithelialization in SPARC-null mice was probably not compromised.
SPARC-null mice and their cells should provide a useful system to investigate how a matricellular protein regulates pleiotropic functions through cell migration and how its absence alters biological processes.
One day after surgery a clear thin film of dried exudate covered the wounds in the wild-type and SPARC-null mice.
It is generally accepted that the driving force for cell movement is provided by the dynamic reorganization of the actin cytoskeleton, directing protrusion (lamellipodia and filopodia) at the front of the cell and retraction at the rear [ 30 31 ] . Although we have not examined the ultrastructure of the dermal fibroblasts at the edge of wound sites, we showed previously by electron microscopy that in the lens of SPARC-null mice numerous cellular processes extended into the ECM of the lens capsule [ 23 ] . We further showed that, in contrast to the abnormal filopodial projections at the lens cell-ECM interface, cell-cell contacts between the neighboring lens epithelial cells and between the lens epithelial and fiber cells were normal [ 23 ] . The results indicate that disassembly of cell-cell contacts between lens cells is not taking place, despite the forward movement of the lens cells into the ECM of the capsule.
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