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SPAM1 is Immunolocalized in the Principal Cells of the Epididymal Epithelium
In all LM epididymal samples from humans (Subjects 1 and 3 corpus, Subject 2 caput/corpus) and macaques (#1, corpus and 2, cauda) the expected 320 bp SPAM1 cDNA fragment was amplified in the RT-PCR reactions.
The finding of conserved expression patterns of epididymal SPAM1 between humans and mice is supported by the findings in the promoter of the human gene.
Consistent with epididymal expression, putative androgen responsive elements (AREs) were discovered in the murine Spam1 5'-flanking region [ 12 ] .
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