Example sentences for: smrt

How can you use “smrt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • SMRT, silencing mediator of retinoid and thyroid hormone receptors

  • Since ERβ bound N-CoR and SMRT in the presence of estrogens, we investigated the possible involvement of corepressors in the actions of agonist-bound ERβ in vivo . To perform this experiment, we examined the effect of the HDAC inhibitor trichostatin A (TSA) on ERβ activity in transiently transfected HeLa cells.

  • Intriguingly, human SMRT contains a sequence insertion at the position of the hydrophobic pair in the N-CoR β-box, which apparently leads to deletion of both residues (N-CoR/RMLS>SMRT/RLqagvmaS) [ 52 ] . Perhaps SMRT contains a different NR interacting motif or the N-CoR NR box sequence may be more complex than we have initially reported here.

  • In the absence of cognate hormone, several nuclear receptors actively repress transcription of target genes via interactions with the nuclear receptor corepressors SMRT and NCoR.

  • Similar agonist-dependent interactions could be observed between ERβ and the alternate NR corepressor SMRT in vitro (Fig.


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