Words similar to smrt

Example sentences for: smrt

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Finally, SMRT also binds ERβ in the presence of estrogens, but we have not explored the structural features that promote this interaction.
NRs generally interact with the corepressors N-CoR and SMRT either in the absence of ligand, or in the presence of receptor antagonists, and agonists promote corepressor release [ 4 ] . In this study, we demonstrated that ERβ binds to N-CoR in the presence of ER agonists such as estradiol and DES and the phytoestrogens genistein and coumestrol, but not in the presence of SERMs.
Full verification of the importance of ERβ interaction with N-CoR will await demonstration that ERβ recruits N-CoR and SMRT to estrogen-regulated promoters in vivo , and that this event is related to modulation of estrogen response.
Intriguingly, human SMRT contains a sequence insertion at the position of the hydrophobic pair in the N-CoR β-box, which apparently leads to deletion of both residues (N-CoR/RMLS>SMRT/RLqagvmaS) [ 52 ] . Perhaps SMRT contains a different NR interacting motif or the N-CoR NR box sequence may be more complex than we have initially reported here.
Thus, N-CoR and SMRT and their associated HDACs are excellent candidates to explain some of the differential behaviors of the ER isoforms.