Words similar to smrt
Example sentences for: smrt
How can you use “smrt” in a sentence? Here are some example sentences to help you improve your vocabulary:
The fact that the mode of ERβ interaction with N-CoR resembles that of NRs with coactivators [ 4 ] , or with corepressors that modulate the activity of liganded NR complexes, such as RIP140 [ 10 ] , raises the possibility that ERβ may be able to recruit N-CoR and SMRT to estrogen-regulated promoters in response to agonists and that the balance of overall ERβ activity in the presence of estrogens may be regulated by competition between p160s and corepressors for the same ERβ AF-2 surface.
The PGC-1 related protein PERC also binds ERα preferentially, and potentiates ERα activity more strongly than that of ERβ [ 38 ] . We recently observed that ERα binds the C-terminal NR interacting regions of N-CoR and SMRT in the presence of SERMs but not estrogens [ 39 ] . In this study, we report that ERβ interactions with N-CoR and SMRT are promoted by agonists and inhibited by SERMs.
Intriguingly, human SMRT contains a sequence insertion at the position of the hydrophobic pair in the N-CoR β-box, which apparently leads to deletion of both residues (N-CoR/RMLS>SMRT/RLqagvmaS) [ 52 ] . Perhaps SMRT contains a different NR interacting motif or the N-CoR NR box sequence may be more complex than we have initially reported here.
NRs generally interact with the corepressors N-CoR and SMRT either in the absence of ligand, or in the presence of receptor antagonists, and agonists promote corepressor release [ 4 ] . In this study, we demonstrated that ERβ binds to N-CoR in the presence of ER agonists such as estradiol and DES and the phytoestrogens genistein and coumestrol, but not in the presence of SERMs.
Similar agonist-dependent interactions could be observed between ERβ and the alternate NR corepressor SMRT in vitro (Fig.
Loading...