Example sentences for: smo

How can you use “smo” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Similarly, specific point mutations in the transmembrane helices of Smo are capable of constitutively stimulating the pathway, effectively bypassing Ptc inhibition [ 3 ] . At present, a controversy surrounds the mechanism by which Ptc inhibits Smo.

  • Such a model cannot accommodate our observations with the gain-of-function Smo mutant.

  • Our biochemistry experiments (above) show that the agonist modulates Smo levels, and thus may activate Hh signaling by directly binding Smo.

  • Having established an in vitro binding assay for the Hh agonist to Smo, we next tested whether the Ptc-independent Hh antagonists could selectively compete with the interaction.

  • A signaling pathway coupler, or effector (in blue), is proposed to bind the activated state of Smo wtso as to generate a complex competent to initiate Hh signaling.


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