Words similar to smo

Example sentences for: smo

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i values of the Hh antagonists were seven-fold higher on the Smo act- compared to the Smo wt-containing membranes for both KAAD-cyclopamine (38.
Although there is clear structural homology between Smo and other GPCRs, endogenous ligands have yet to be discovered.
This supports the model that all of these small-molecule modulators of Hh signaling are direct ligands of Smo.
Thus we introduce a ternary complex model (Figure 8b), used traditionally to describe the behavior of GPCRs in binding studies with agonist and antagonists [ 31 ] , as well as constitutively active receptors [ 29 ] . The ternary complex model for Hh signaling suggests that there are two independent binding sites on Smo wt, one specific for the agonist and another specific for antagonists.
Early models of Hh signaling proposed a Hh-regulated Ptc-Smo complex that directly controlled the conformation of Smo, making endogenous ligands unnecessary.