Example sentences for: smo

How can you use “smo” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Testing Smo as the molecular target

  • We next compared binding of KAAD-cyclopamine, Cur61414 and Hh-Ag 1.5 to a constitutively active mutant of Smo (Smo act) or to wild-type Smo (Smo wt).

  • Throughout the discussion the term 'coupler/effector' is used to describe an unknown molecule that binds activated Smo in such a way as to trigger signal transduction.

  • The Hh-signaling pathway comprises three main components: the Hh ligand; a transmembrane receptor circuit composed of the negative regulator Patched (Ptc) plus an activator, Smoothened (Smo); and finally a cytoplasmic complex that regulates the Cubitus interruptus (Ci) or Gli family of transcriptional effectors.

  • It is plausible that some or all of these effects on Smo result from a feedback inhibition mechanism that targets the activated Smo receptor.


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