Words similar to smo

Example sentences for: smo

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These results strongly support the model, initially hypothesized for cyclopamine [ 11 ] , that the reduced potency observed for Hh antagonists on Smo act-expressing cells is directly due to a reduced affinity of the antagonist for the mutated Smo protein.
To interpret the results of the competition binding studies, we assume that the mutation in Smo act, like those in constitutively activate mutants of other GPCRs [ 29 ] , indirectly influences ligand binding by creating a change in the normal equilibrium between the different conformations of Smo.
Using Smo act- and Smo wt-containing membranes, we then performed competition binding studies by adding increasing concentrations of unlabeled Hh-Ag 1.5, KAAD-cyclopamine or Cur61414 in the presence of [ 3H]-Hh-Ag 1.5 (0.
Interestingly, while we did observe stabilization of Smo by Hh in our mammalian cell experiments (Figure 5), we did not detect Smo phosphorylation or translocation to the plasma membrane (data not shown).
Although no compelling data have been presented that directly link classic G-protein activation [ 37 ] to the canonical Hh pathway involving Ci/Gli stimulation [ 2 ] , recent studies show that under certain conditions Smo can engage G-protein subunits in a Ptc-dependent manner [ 38 ] and that G-protein-mediated cAMP modulation may underlie certain effects of Hh on neuronal tissue [ 39 ] .