Words similar to smo
Example sentences for: smo
How can you use “smo” in a sentence? Here are some example sentences to help you improve your vocabulary:
Similarly, specific point mutations in the transmembrane helices of Smo are capable of constitutively stimulating the pathway, effectively bypassing Ptc inhibition [ 3 ] . At present, a controversy surrounds the mechanism by which Ptc inhibits Smo.
Such a model cannot accommodate our observations with the gain-of-function Smo mutant.
Our biochemistry experiments (above) show that the agonist modulates Smo levels, and thus may activate Hh signaling by directly binding Smo.
Having established an in vitro binding assay for the Hh agonist to Smo, we next tested whether the Ptc-independent Hh antagonists could selectively compete with the interaction.
A signaling pathway coupler, or effector (in blue), is proposed to bind the activated state of Smo wtso as to generate a complex competent to initiate Hh signaling.