Example sentences for: smo

How can you use “smo” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Furthermore, studies with the agonist and several antagonists of Hh signaling suggest that Smo can be activated or inhibited by direct interaction with small-molecule ligands.

  • The ideas proposed for the Drosophila system, in which Ptc may affect the levels of Smo or its subcellular localization, are easily accommodated.

  • Next, we sought to generate association, dissociation and saturation-binding curves, in order to derive affinity constants for the interaction of the Hh agonist and Smo.

  • Furthermore, the gain-of-function Smo mutation renders the protein less sensitive to the inhibitors, presumably because the amino-acid substitution directly stabilizes or induces an active conformation.

  • It is plausible that some or all of these effects on Smo result from a feedback inhibition mechanism that targets the activated Smo receptor.


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