Example sentences for: signalling

How can you use “signalling” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Therefore, we wished to determine what effects the down-regulation of the EGFR would have on ERK signalling via the δ-OR.

  • Furthermore, our previous work has shown that, in invasive breast cancer cells, Ets proteins activate the PTHrP P3 promoter in cooperation with Smad3 [ 19 ] . In this context it is interesting to note that TGFβ signalling seemed to target the ets-1 and ets-2 gene (Fig.

  • Malignant tumor cells frequently show deregulation and hyperactivation of signalling pathways, one of which is represented by the TGFβ signal transduction pathway [ 1 ] . TGFβ has been shown to potently inhibit proliferation of most epithelial, endothelial and hematopoietic cells [ 2 ] . However, during tumor progression malignant cells may become refractory to TGFβ-mediated cell cycle arrest.

  • The specific role of each enzyme in the regulation of retinoid signalling may depend on the species, cell type, and developmental status of the cell.

  • In addition, IFNg interaction with the receptor leads to p38MAPK-mediated phosphorylation of STAT1 on Serine 727 [ 17 ] . The phosphorylated STAT1 dimerizes and translocates into the nucleus where it activates transcription of several other factors including CIITA [ 31 ] . Although the results of this study do not allow us to describe the exact mechanism of PMA involvement in IFNg signalling in LS1034 cell, at least two non-mutually exclusive scenarios can be hypothesized:


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