Words similar to signalling
Example sentences for: signalling
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Other mechanisms that may participate in the RU 486-induced inhibition of hepatic apoptosis include the fact that this compound blocks the inhibitory effect of glucocorticoids on suppressors of cytokine signalling in the liver [ 8 ] . This family of proteins is induced by growth hormones and cytokines, and is strongly repressed in vivo by glucocorticoids [ 8 ] . Up-regulation of these proteins by RU 486 [ 8 ] , coupled with significant increase in hepatic TNFα level found in animals treated with RU 486 [ 12 ] , may contribute to the inhibition of apoptosis observed in our study (Fig 1B).
1. PMA could act through the JAK-STAT signalling pathway.
in vitro work showing that blockade of TGF-β signalling did not abrogate the growth inhibitory effect of tamoxifen on breast cancer cells [ 26].
Finally, CD81 signalling has been shown to have an effect on the Th1/Th2 balance of immune responses.
Changing the interaction of peptide, MHC class II molecules, T cell receptors and other antigen-presenting cell specific ligand interactions to foster stronger, higher affinity T cell signalling has been shown in mice to skew T cell differentiation from Th2 to Th1-like patterns [ 40 41 42 43 44 45 46 47 48 49 50 ] . Differences in Th-differentiation patterns have downstream effects on the type of immune response mounted, and in particular on the isotypes of antibody expressed.