Words similar to signalling
Example sentences for: signalling
How can you use “signalling” in a sentence? Here are some example sentences to help you improve your vocabulary:
Therefore, we wished to determine what effects the down-regulation of the EGFR would have on ERK signalling via the δ-OR.
In addition, in early 2003, they reported that, as in other sensory systems, a single signalling pathway involving the ion channel TRPM5 and PLCβ2, a phospholipase that produces a TRPM5 activator, lies downstream of the bitter, sweet, and umami receptors.
Furthermore, our previous work has shown that, in invasive breast cancer cells, Ets proteins activate the PTHrP P3 promoter in cooperation with Smad3 [ 19 ] . In this context it is interesting to note that TGFβ signalling seemed to target the ets-1 and ets-2 gene (Fig.
Evidence has been accumulated that TGFβ promotes late-stage tumorigenesis by stimulating angiogenesis and invasive behaviour of tumor cells, enhancing immunosuppression and supporting epithelial-mesenchymal transition of cancer cells [ 4 ] . Furthermore, TGFβ is believed to be part of a vicious circle in bone metastases as it gets released from osteoclast-degraded bone substance and subsequently stimulates PTHrP gene expression in nearby metastatic cancer cells which in turn leads to an activation of osteoclastic bone resorption [ 11 ] . Therefore, it is of great interest to understand in more detail the molecular aspects of TGFβ-mediated gene expression in metastatic breast cancer cells and to explore ways to interfere with this tumorigenic signalling.
in vitro work showing that blockade of TGF-β signalling did not abrogate the growth inhibitory effect of tamoxifen on breast cancer cells [ 26].
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