Example sentences for: signaling

How can you use “signaling” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, it is not clear if Btk alone is sufficient to mimic aspects of BCR signaling, nor is it known whether all downstream signals mediated by Btk are PLCγ2-dependent.

  • Although the mechanism(s) by which cytokines induce apoptosis vary among cell types, it is presumed that it involves either an increase in reactive oxygen species (ROS) or activation of stress-related signaling pathways.

  • Since it is well established that RANK signaling is mediated primarily through TRAF6 [ 35 ] and that IFN-γ signaling is mediated primarily through STAT1 [ 36 37 ] , we examined their expression by western blot.

  • On the other hand, it has been previously demonstrated that direct activation of adenylate cyclase by Forskolin or cholera toxin, inhibition of cAMP-specific phosphodiesterase, and treatment with a cell permeable cAMP analog, induces a rise in intracellular cAMP [ 22 23 24 25 26 ] . Since cAMP is known to modulate the expression of CD8 in mice [ 27 ] , we sought to determine whether cAMP-dependent protein kinase (PKA)-mediated signaling plays a role in modulating the mRNA levels of CD3, CD4, and CD8 in ex vivo examined human thymocytes.

  • Recent data argue that Itk interacts directly with Slp-76 and Grb2 to participate in a LAT-nucleated T cell signaling complex involved in PLC-γ activation [ 5, 29].


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