Words similar to signaling
Example sentences for: signaling
How can you use “signaling” in a sentence? Here are some example sentences to help you improve your vocabulary:
The observation that LRP5ΔN activates the Wnt/Wg signaling pathway in a Dsh-independent manner [ 14 ] , and our data with overexpressed LRP6ΔN and LRP6, further support this proposal.
BMP-5 signaling may be modulated by noggin and follistatin since these BMP antagonists were observed to inhibit the dendrite-promoting activity of BMP-5.
Similarly to nuclear receptors and to other transcription factors, STAT proteins can interact with coactivators to modulate their transcriptional activity [ 9 10 11 12 ] . Other reports have shown direct interactions between several members of the JAK/STAT signaling pathway with SHRs [ 13 14 15 16 ] . Stat3 is one of the seven members of the STAT family of proteins that has been shown to modulate the expression of several genes related to control cell cycle, proliferation and apoptosis, such as Cyclin D1, c-myc, and Bcl-xL, respectively [ 17 ] . Accordingly, alterations in the activity of STAT3 have been associated with cell transformation and cancer progression [ 18 19 20 ] .
The lexicon and example models presented so far have focused primarily on cell signaling and transduction pathways where intramolecular site-site interactions (for example conformational regulation of kinase activity) are prominent.
The hedgehog ( hh ) gene was identified two decades ago in Drosophila as a critical regulator of cell-fate determination during embryogenesis [ 1 ] . Subsequent work in several model systems has defined and characterized the Hh gene family that encodes highly conserved secreted signaling proteins (for review see [ 2 ] ). Hedgehog (Hh) proteins are synthesized as approximately 45 kDa precursors that autoprocess in an unprecedented fashion, resulting in the covalent attachment of a cholesterol moiety to the amino-terminal half of the precursor [ 2 ] . This processed amino-terminal domain, Hh-Np, is responsible for the activation of a unique and complex signaling cascade that is essential for controlling cell fate throughout development and into adulthood [ 2 ] . In mammals there are three Hh-family proteins: Sonic (Shh), Indian (Ihh), and Desert (Dhh).
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