Words similar to signalosome

Example sentences for: signalosome

How can you use “signalosome” in a sentence? Here are some example sentences to help you improve your vocabulary:

uncovered a novel connection between the COP9/signalosome (CSN) and cullin neddylation [ 10].
These findings have lead to the hypothesis that Btk and PLCγ2 are components of the same signaling unit, or signalosome [ 30].
COP10, which has been shown to interact with AtCOP1 in yeast two-hybrid experiment, encodes a ubiquitin conjugating enzyme (E2) variant [ 44 ] . The COP9 signalosome, an eight-subunit complex homologous to the lid subcomplex of the 26 S proteasome [ 45 ] , directly associates with SCF E3 complex and promotes deneddylation of the cullin subunit of SCF in both plant and animal cells [ 46 47 48 49 ] . The exact relationship between COP1 and the COP9 signalosome remains obscure; it is known, however, that in Arabidopsis the COP9 signalosome is required for COP1 to accumulate in the nucleus in the dark [ 29 ] . Although COP1 most likely plays a role in regulating protein degradation, attempts in reconstituting ubiquitination of HY5 by AtCOP1 have been unsuccessful.
In the present study, while we cannot rule out the possibility that Btk:ER activates PLCγ2 in combination with other uncharacterized pathways, our data strongly support the Btk/PLCγ2 signalosome model by showing that PLCγ2 is absolutely required for Btk:ER-induced calcium, MAPK and apoptosis responses.
The mechanism may involve stabilization by Btk of the PLCγ2 complex, or 'signalosome' [ 30], in an optimal conformation or subcellular location.