Example sentences for: signalosome

How can you use “signalosome” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In the present study, while we cannot rule out the possibility that Btk:ER activates PLCγ2 in combination with other uncharacterized pathways, our data strongly support the Btk/PLCγ2 signalosome model by showing that PLCγ2 is absolutely required for Btk:ER-induced calcium, MAPK and apoptosis responses.

  • Two subunits of the COP9 signalosome, CSN2 and CSN6, were located both in the cytosol and the NP fractions, but not in the NE fractions (Fig 3B).

  • These findings have lead to the hypothesis that Btk and PLCγ2 are components of the same signaling unit, or signalosome [ 30].

  • Cyclin A, but not cyclin E levels were also suppressed by MIB in an AR-dependent manner, while the levels of the COP9/signalosome subunit CSN5/JAB1 and tubulin remained constant (Fig.

  • uncovered a novel connection between the COP9/signalosome (CSN) and cullin neddylation [ 10].


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