Words similar to signalosome

Example sentences for: signalosome

How can you use “signalosome” in a sentence? Here are some example sentences to help you improve your vocabulary:

These findings have lead to the hypothesis that Btk and PLCγ2 are components of the same signaling unit, or signalosome [ 30].
This finding is distinct from the observation for AtCOP1, which exists mainly as a homodimer [ 32 ] . In addition, the HsCOP1 complexes differ from the HsCOP9 signalosome complexes in size, as suggested by the different peak fractions (Fig 4).
In the present study, while we cannot rule out the possibility that Btk:ER activates PLCγ2 in combination with other uncharacterized pathways, our data strongly support the Btk/PLCγ2 signalosome model by showing that PLCγ2 is absolutely required for Btk:ER-induced calcium, MAPK and apoptosis responses.
While our study suggests that SKP2 is an important player in p27 regulation in prostate cancer cells, recent studies have also implicated another protein, CSN5/JAB1, in p27 regulation [ 54 55 ] . CSN5 is a subunit of the COP9/signalosome (CSN) complex [ 56 57 58 59 ] , but also forms distinct complexes apparently lacking CSN subunits [ 55 60 61 62 ] . Overexpression of CSN5 in NIH3T3 cells causes p27 export from the nucleus and ectopic degradation [ 54 ] . Notably, like SKP2 [ 33 36 37 38 ] , CSN5 was found to be overexpressed in cancers devoid of p27 [ 63 ] . However, our studies did not reveal any effect of MIB on CSN5 expression.
Cyclin A, but not cyclin E levels were also suppressed by MIB in an AR-dependent manner, while the levels of the COP9/signalosome subunit CSN5/JAB1 and tubulin remained constant (Fig.