Words similar to signalosome

Example sentences for: signalosome

How can you use “signalosome” in a sentence? Here are some example sentences to help you improve your vocabulary:

In the present study, while we cannot rule out the possibility that Btk:ER activates PLCγ2 in combination with other uncharacterized pathways, our data strongly support the Btk/PLCγ2 signalosome model by showing that PLCγ2 is absolutely required for Btk:ER-induced calcium, MAPK and apoptosis responses.
CSN: COP9/signalosome
uncovered a novel connection between the COP9/signalosome (CSN) and cullin neddylation [ 10].
COP10, which has been shown to interact with AtCOP1 in yeast two-hybrid experiment, encodes a ubiquitin conjugating enzyme (E2) variant [ 44 ] . The COP9 signalosome, an eight-subunit complex homologous to the lid subcomplex of the 26 S proteasome [ 45 ] , directly associates with SCF E3 complex and promotes deneddylation of the cullin subunit of SCF in both plant and animal cells [ 46 47 48 49 ] . The exact relationship between COP1 and the COP9 signalosome remains obscure; it is known, however, that in Arabidopsis the COP9 signalosome is required for COP1 to accumulate in the nucleus in the dark [ 29 ] . Although COP1 most likely plays a role in regulating protein degradation, attempts in reconstituting ubiquitination of HY5 by AtCOP1 have been unsuccessful.
Two subunits of the COP9 signalosome, CSN2 and CSN6, were located both in the cytosol and the NP fractions, but not in the NE fractions (Fig 3B).