Words similar to signalosome

Example sentences for: signalosome

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Two subunits of the COP9 signalosome, CSN2 and CSN6, were located both in the cytosol and the NP fractions, but not in the NE fractions (Fig 3B).
These findings have lead to the hypothesis that Btk and PLCγ2 are components of the same signaling unit, or signalosome [ 30].
uncovered a novel connection between the COP9/signalosome (CSN) and cullin neddylation [ 10].
This finding is distinct from the observation for AtCOP1, which exists mainly as a homodimer [ 32 ] . In addition, the HsCOP1 complexes differ from the HsCOP9 signalosome complexes in size, as suggested by the different peak fractions (Fig 4).
While our study suggests that SKP2 is an important player in p27 regulation in prostate cancer cells, recent studies have also implicated another protein, CSN5/JAB1, in p27 regulation [ 54 55 ] . CSN5 is a subunit of the COP9/signalosome (CSN) complex [ 56 57 58 59 ] , but also forms distinct complexes apparently lacking CSN subunits [ 55 60 61 62 ] . Overexpression of CSN5 in NIH3T3 cells causes p27 export from the nucleus and ectopic degradation [ 54 ] . Notably, like SKP2 [ 33 36 37 38 ] , CSN5 was found to be overexpressed in cancers devoid of p27 [ 63 ] . However, our studies did not reveal any effect of MIB on CSN5 expression.