Words similar to severe

Example sentences for: severe

How can you use “severe” in a sentence? Here are some example sentences to help you improve your vocabulary:

In addition, the success of the yeast two-hybrid technique suggests that the geometric constraints on transactivation are not severe (i.e.
Since the influence of non-specific binding is more severe for probes where no or little specific hybridization occurs [ 8 ] , we treat the problem as one of detecting a threshold value that is both determined by the highest signals attributable to spots representing non-specific hybridization and the lowest signals from spots where sequence specific hybridization must be assumed.
HIV-1 infection can cause extensive neuronal loss and clinically, a severe dementia.
A correlation between sequence conservation and severe phenotype by RNAi had previously been shown by comparison of C. elegans to genomes from the distant phyla Saccharomyces, Drosophila and human [ 63 64 ] . Here we show a similar trend following detection of homology to expressed genes in other nematode species.
Studies were classified as 'controlled' if they included a blinded placebo comparison with drotrecogin alfa (activated; Xigris ®, Eli Lilly and Company, Indianapolis, IN, USA); 'open-label' if drotrecogin alfa (activated) was administered in a single arm study conducted at prospectively identified and trained investigative sites; or 'compassionate-use' if drotrecogin alfa (activated) was provided on emergent request to noninvestigator clinicians treating patients with severe sepsis.