Example sentences for: serpin

How can you use “serpin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Plasminogen activator inhibitor-1 (PAI-1) is a serine proteinase inhibitor in the serpin superfamily [ 1 2 3 ] . This 50 kDa glycoprotein is apparently the most important physiological inhibitor of tissue-type plasminogen activator (tPA) and of urokinase plasminogen activator (uPA).

  • This substantiates previous mutagenesis studies, which demonstrated that repulsive interactions and/or lack of productive electrostatic interactions between Glu39 and Glu192 of thrombin and PAI-1 are responsible for the slow reaction of thrombin with this serpin.

  • Our results are concordant with previous study, [ 25 ] which suggests that serpin body-protease body interactions play significant roles in determining serpin inhibitory activity against target proteases.

  • Another cluster A gene is alpha 1 -antichymotrypsin (ACT), a member of the serine proteinase inhibitor (serpin) family, which inhibits the neutrophil proteinase cathepsin G and mast cell chymases, and protects the lower respiratory tract from damage by proteolytic enzymes [ 28].

  • Biochemically, PEDF is a 50-kDa glycoprotein with structural homology to members of the serine-protease inhibitor (serpin) superfamily [ 3 15 ] . However, it has no inhibitory effects on proteases.


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