Words similar to serm

Example sentences for: serm

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In a recent landmark trial, tamoxifen, a hormonally active selective estrogen receptor modulator (SERM), was shown to decrease the risk of invasive breast cancer by 49% in asymptomatic, but at-risk women [ 1].
In a recent landmark trial [ 1], tamoxifen, a hormonally active SERM, was shown to decrease the risk of invasive breast cancer by 49% in asymptomatic, but at-risk women.
While the ER isoforms have contrasting effects on AP-1 activity in the presence of estrogens, ERα truncations that lack the NTD and ERβ both enhance AP-1 activity in the presence of SERMs [ 30 31 ] . Mutational analysis of ERα action at AP-1 sites suggests these effects may be related to N-CoR binding [ 39 ] , and we have proposed that SERM action at AP-1 sites may therefore involve contacts with corepressors [ 31 51 ] . The fact that ERα and ERβ show completely different ligand preferences of interaction with N-CoR suggests that the target for SERM activation at AP-1 sites may not be N-CoR in both cases.
Another SERM, raloxifene, also shows promise [ 29].
SERM Selective estrogen receptor modulator(s)