Words similar to ser
Example sentences for: ser
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Because Val and Met are both non-polar amino acids, and Ser and Gly are both polar and uncharged amino acids, those amino acid substitutions between ZAS-N and ZAS-C may result in minor changes in the tertiary structure of the zinc fingers which account for the subtle differences in the DNA binding properties of the ZAS-N and ZAS-C domains.
The optimal consensus site for MAP kinase phosphorylation isPro-X-(Ser/Thr)-Pro, however in some cases the upstream Pro is not required and a minimal sequence of Ser-Pro or Thr-Pro is phosphorylated (for review, see Davis, 1993 [ 21 ] ). The 5-HT 2C receptor site is just such a minimal sequence of Ser-Pro and it is the only MAP kinase site we identified within the receptor's presumed intracellular domains.
Subdomain VIII contains the TXXYXAPE motif in Ser/Thr kinases and PXXWXAPE in Tyr kinases as noted previously [ 11].
cPLA 2 is phosphorylated by mitogen activated protein (MAP) kinases, including p42/p44 ERKs and p38, on Ser 505in vitro [ 16 17 ] and in response to receptor stimulation [ 16 18 19 20 21 ] . In addition to phosphorylation by MAP kinase, it has been shown that cPLA 2 is also phosphorylated on Ser 727by MAPK-interacting kinase I (MNKI) [ 22 ] and on Ser 515by calcium/calmodulin-dependent protein kinase II [ 23 ] . Phosphorylation of these sites may also play a role in regulating cPLA 2 function in certain cell models.
Missense mutations in the enzyme thymidine phosphorylase (TP) (Gly145 → Arg, Gly153 → Ser, Lys222 → Ser, Glu289 → Ala and a few others) have been found in multiple MNGIE patients, and are believed to cause the pathology [ 22].
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