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Example sentences for: selected
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For example, Herschlag and co-workers have previously shown that a nucleobase could complement an abasic site within the hammerhead ribozyme, restoring cleavage activity [ 1 ] . Similarly, Porta and Lizardi engineered a hammerhead ribozyme that assumed an inactive secondary structure; upon the addition of an oligonucleotide that disrupted the engineered secondary structure, the ribozyme was activated [ 2 ] . More recently, it has previously been shown that many selected nucleic acid binding species (aptamers) undergo conformational changes upon ligand binding [ 3 4 5 6 ] In addition, when aptamers are conjoined to ribozymes, the ligand-induced conformational changes in the aptamers frequently modulate the structures and hence the activities of the ribozymes [ 7 8 9 ] For example, binding of theophylline to the anti-theophylline aptamer [ 10 ] modulates the conformation of residue [ 11 12 ] and the overall stability of the aptamer [ 10 13 ] . Appending the anti-theophylline aptamer to the hammerhead ribozyme allowed cleavage activity to be modulated by 110-fold by theophylline [ 13 ] . Similarly, appending the anti-theophylline aptamer to a small ribozyme ligase (L1) generated an aptazyme that was activated 1,600-fold by saturating theophylline concentrations [ 14 ] .
- Whenever a unit referred to in paragraph (1) elects to calculate itsbaseline as provided in clause (ii) of paragraph (1), the Administrator shall allocate allowances for the unit pursuant to section 412(a), this section, and section 414 (as basic Phase II allowance allocations) in an amount equal to the baseline selected multiplied by the lower of the average annual emission rate for such unit in 1989, or 1.0 lbs./mmBtu.
The L44 bronchial adenocarcinoma was selected from among ten rat tumours of different histological origin, as being very poorly permissive to adenovirus.
Exposed females were given continuous access to adult male scentmarks from 90 days and randomly selected for necropsy at 105 (n = 5) and 130 days (n = 5).
Design features Site selection depends on program diversity, cannot be used with highly diverse programs; best, worst, representative, typical, or cluster bases appropriate; must keep number of cases manageable or risk becoming minisurvey, can use survey before or after to check generalizability or mix survey with concurrent case studies selected for special purposes; data rely on observation and structured materials, often combine qualitative and quantitative data; analysis uses varying degrees of formalization around emergent or predetermined themes; reports are usually thematic and describe site differences and explain these; variation in degree of integration of data across sites and of findings from different methods
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