Words similar to selectin
Example sentences for: selectin
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[ 31 ] demonstrated that thrombin activation of PAR1 led to deposition of P-selectin, a leukocyte adhesion molecule, on the surfaces of endothelial cells.
The TK-1 lymphocyte cell line used in this assay expresses high levels of the α4β7 integrin, [ 39 41 ] which can interact with multiple ligands including mucosal addressin-1 (MAdCAM-1), as well as VCAM-1, L-selectin and fibronectin [ 42 ] . In this system, TNF-α stimulated TK-1 adhesion to SVEC4-10 endothelial cells is at least 50% MAdCAM-1 dependent [ 41 ] . SVEC monolayers were grown in 48-well plates as described, and to activate endothelium, the monolayers were incubated with TNF-α (1 ng/ml) for 24 h.
Chinese Hamster Ovary (CHO) cells expressing human E- or P-selectin have been previously described [ 6 13 ] . Cells were incubated at 37°C in an air/5% CO 2 atmosphere.
To determine whether adenoviral transduction changed their activation status, resting CD4 +T cells were examined for expression of the early activation markers CD62L (L-selectin) and CD25 (IL-2Rα).
The selectins are a family of molecules on which neutrophils will roll but not firmly adhere [ 20 ] . Table 2shows that significant differences in rolling velocities of neutrophils were seen on E- versus P-selectin coated surfaces in agreement with previous observations.