Words similar to selectivity
Example sentences for: selectivity
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It has been suggested that perhaps cytoplasmic proteins are not exported in prl suppressor strains because they fold rapidly and escape recognition by SecB, while secretory proteins, even those lacking a signal sequence, fold more slowly, allowing time for SecB recognition and binding [ 5 13 ] . SecB binds to a variety of unfolded proteins in vitro [ 24 25 ] , although binding appears to be more selective in vivo [ 26 ] . This selectivity may be based on the slower folding characteristics of secretory proteins.
Results are shown in Figure 4and Table 5. Since library construction was based on peptides previously selected for binding and selectivity to specific RNAs, the number of target-specific clones increased dramatically following in vitro maturation.
As a result, Top67 could position itself in the absence of ZD domain at the junction of double- and single-stranded DNA for subsequent DNA cleavage, as previously observed for intact topoisomerase I [ 8 ] . Reversal of DNA cleavage also took place readily with Top67 upon addition of 1 M NaCl and 4 mM MgCl 2 . The ZD domain also was not required for selectivity of a cytosine in the -4 position relative to the cleavage sites.
Further, the annotation pipeline provides a graded reliability index of functional prediction reliability ranging from A to E based on extensive benchmarking of selectivity versus sensitivity (N.N.A.
Analysis of biophores #1, #2 (#4, #5) showed that both of them occur in substituted 5-[4-(benzyloxy) phenyl]-1,3,4-oxadiazol-2-(3H)-ones and their analogs (Figure 1), many of which are known to be strong MAO-B inhibitors [ 9 ] . Biophore #2 represents a flexible -CH 2 O- bridge between aryl moieties and was found to enhance the activity and selectivity of the inhibitors as shown in the original work [ 9 ] . Biophores #1 and #2 include aromatic moieties, whose main function is presumably to bind to the hydrophobic site of MAO.
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