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Example sentences for: segregates
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Among the intrinsic factors underlying asymmetric division, the interactions of the Numb differentiation-associated protein with Notch proliferation-associated signaling is the model most widely studied, ranging from bacteria, yeast, and Drosophila to mammals [ 30 ] . When the neuronal progenitor cells undergo asymmetric division (20% in neuronal tissue cell culture) they produce neuronal daughter cells to which Numb protein segregates preferentially, and such daughter cells show an enhanced differentiation of neuronal processes [ 45 ] . Interestingly, Numb is firstly associated with one pole of the plasma membrane of a dividing cell, and subsequently with one of the two resulting nuclei [ 29 45 ] . Our study indicates that preservation of nuclear ERα in one of two postmitotic cells is associated with the ability of CT to replicate and diminution of ERα and appearance of nuclear ERβ dictates a generation of a daughter cell that is committed to differentiate (Fig.
Thus far, this phenotype segregates as an autosomal dominant trait and maps to either FEOM3 on 16qter [ 7 ] or to FEOM1 [ 24 ] .
Atrial fibrillation segregates as an autosomal dominant disease characterized by atrial fibrillation on an electrocardiogram [ 1 ] . We diagnosed atrial fibrillation in five families from Spain in which the arrhythmia was the primary manifestation and not associated with any gross cardiac or metabolic abnormality [ 1 ] . Genetic linkage analysis was performed and the locus responsible for atrial fibrillation in our family was mapped to 10q22 between markers D101786 and D10S1630, an area of about 11 cM [ 1 ] . We proceeded with the candidate gene approach and DLG5 was on of the genes mapped to the critical region between the flanking markers [ 2 ] . This gene belongs to the MAGUK (Membrane Associated Gyanylate Kinase) family of proteins known to form scaffolds for proteins involved in intracellular signal transduction [ 2 ] . The MAGUK family of proteins has been extensively studied in recent years and shown to play a role in the formation of cell junctions, maintenance of cell shape, [ 3 4 5 ] and clustering of channel proteins at the cell surface [ 6 7 8 ] . Given its location in our critical region and its function it was selected as a candidate for atrial fibrillation.
and Seriphidium , the Bremer and Humphries [ 2 ] morphologically based cladogram placed four small genera ( Neopallasia, Turaniphytum, Mausolea, Picrothamnus ; with a total of seven species) as closest sisters ( i.e ., segregates) of Artemisia s.s . (the Artemisia -clade sensu Bremer and Humphries), whereas Seriphidium and two small genera ( Kaschgaria, Crossostephium ; 3 species total) were placed outside the Artemisia -clade as allies to Artemisia s.s . In addition, Sphaeromeria, Filifolium, Ajaniopsis , and Stilnolepis (13 species total) were sister to this clade of eight genera that included Artemisia s.s.
We used robust, model-free, allele-sharing genetic analyses to address the complexity, we studied a relatively genetically homogenous population, and we verified that all putative IAs were saccular [ 1 20 41 42 43 ] . It is expected that a genetically homogeneous population, particularly one with a recent population bottleneck [ 37 38 ] , segregates for fewer disease loci thereby allowing a smaller sample size to be informative.
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