Words similar to segregates
Example sentences for: segregates
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Atrial fibrillation segregates as an autosomal dominant disease characterized by atrial fibrillation on an electrocardiogram [ 1 ] . We diagnosed atrial fibrillation in five families from Spain in which the arrhythmia was the primary manifestation and not associated with any gross cardiac or metabolic abnormality [ 1 ] . Genetic linkage analysis was performed and the locus responsible for atrial fibrillation in our family was mapped to 10q22 between markers D101786 and D10S1630, an area of about 11 cM [ 1 ] . We proceeded with the candidate gene approach and DLG5 was on of the genes mapped to the critical region between the flanking markers [ 2 ] . This gene belongs to the MAGUK (Membrane Associated Gyanylate Kinase) family of proteins known to form scaffolds for proteins involved in intracellular signal transduction [ 2 ] . The MAGUK family of proteins has been extensively studied in recent years and shown to play a role in the formation of cell junctions, maintenance of cell shape, [ 3 4 5 ] and clustering of channel proteins at the cell surface [ 6 7 8 ] . Given its location in our critical region and its function it was selected as a candidate for atrial fibrillation.
and Seriphidium , the Bremer and Humphries [ 2 ] morphologically based cladogram placed four small genera ( Neopallasia, Turaniphytum, Mausolea, Picrothamnus ; with a total of seven species) as closest sisters ( i.e ., segregates) of Artemisia s.s . (the Artemisia -clade sensu Bremer and Humphries), whereas Seriphidium and two small genera ( Kaschgaria, Crossostephium ; 3 species total) were placed outside the Artemisia -clade as allies to Artemisia s.s . In addition, Sphaeromeria, Filifolium, Ajaniopsis , and Stilnolepis (13 species total) were sister to this clade of eight genera that included Artemisia s.s.
Some reports suggest that IgA deficiency segregates with a HLA haplotype(s) containing A*01, B*08 in some families [ 4 5 6 19 20 ] . Thus, we analyzed the frequencies of the haplotype A*01-B*08 in the present index patients grouped according to presence of normal or subnormal pre-treatment serum concentrations of IgG, IgA, and IgM, respectively.
and its segregates and allies.
Thus far, this phenotype segregates as an autosomal recessive trait and maps to the FEOM2 locus on chromosome 11q13 [ 8 ] , and affected individuals carry homozygous mutations in ARIX [ 5 ] . ARIX encodes a homeodomain transcription factor required for nIII and nIV development in mice and zebrafish [ 22 23 ] . In families with CFEOM3, the CFEOM phenotype is variably expressed.
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