Words similar to secreted
Example sentences for: secreted
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Secreted proteins, like all other proteins, are synthesized in the endoplasmic reticulum (ER) and are specifically packaged into vesicles that bud off from the ER in a GTP-dependent process [ 3, 4].
The CXC chemokines such as IL-8 were originally identified as potent activators and chemoattractants for neutrophils, whereas the CC chemokines such as MCP-1 and RANTES mostly attract monocytes and eosinophils respectively [ 10 ] . Chemokines are secreted in a stimulus-and cell type-specific manner [ 11 12 13 14 15 16 17 ] and are regulated primarily at the level of gene transcription [ 18 19 20 21 22 23 24 ] . The transcriptional promoters of IL-8, RANTES and MCP-1 contain binding sites for the redox-responsive transcription factor NF-κB, which has been shown to be important for their regulation by viral infections and cytokines [ 18 20 23 25 26 27 28 29 30 31 32 33 34 ] .
From 10 6 cells at stage 2, we produced an average of 200–400 clusters with approximately 2,000 cells per cluster; approximately 25% of these cells are C-peptide + and release 0.5%–1% of C-peptide secreted by β-cells.
TGF-β expression is closely associated with an increase in wall shear stress [ 30 31 ] and with different forms of fluid shear stress [ 32 ] , and its function is modulated by variety of factors [ 14 ] . For example, TGF-β1 is secreted in an inactive precursor and requires furin-mediated maturation [ 33 ] . TGF-β1 in turn induces expression of furin.
Along with lumican, claudin-3, KLF2, PS1, VEGF and TNFR-1 mentioned above, these include several secreted proteins (secreted apoptosis related protein 1 and NPDC1) which are also likely to function in coordination with IL-8; several genes from the well-known family of complement factors (C1 esterase, human complement C4A and complement factor B); and several unknown or hypothetical genes.
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