Words similar to secrete
Example sentences for: secrete
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It is well established that, besides the MHCII molecules, IFNg can induce susceptible tumors to upregulate the expression of MHC class I antigens [ 43 ] , tumor associated antigens [ 44 ] , costimulatory molecules [ 45 ] , and heat shock proteins [ 46 ] . In addition, IFNg may have antimetabolic and antiproliferative influence on certain types of tumor cells [ 47 ] . It has also been suggested that IFNg may cause responding tumor cells to secrete angiogenesis inhibitors [ 48 ] . As it is not known which of those IFNg effects are missing or restored by PMA in LS1034 cells, a thorough evaluation of the possible clinical implications of our in vitro findings is quite difficult.
The present study was designed to compare quantitatively the relative effectiveness of these two avenues of protein delivery under controlled conditions in vitro . Cultures of primary human synovial fibroblasts (HSFs) were treated with human IL-1Ra, either administered as the recombinant protein or by co-culture with fibroblasts genetically engineered to express and secrete human IL-1Ra in a constitutive manner.
The present studies indicate that the frequency of CD4 +memory T cells that express IFN-γ in the blood and synovium is comparable, although the percentages that secrete IFN-γ are not known.
The similarities between islet cells and neurons are further underscored by the demonstration of insulin gene transcription in the vertebrate brain [5], although it remains unclear whether these vertebrate neurons produce or secrete insulin protein [6].
Whereas early memory T cells, identified by the CD45RO +, CD27 +phenotype, have the potential to secrete IL-2 and IFN-γ, these cells cannot produce IL-4 and few produce IFN-γ in the absence of IL-2 [ 17, 19].
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