Example sentences for: secretory

How can you use “secretory” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The hypothesis driving the present studies was premised on the observation that prl suppressor strains are able to correctly identify secretory proteins, even in the absence of a signal sequence.

  • Proteolytic processing within the trans-Golgi and the secretory vesicles culminates in the formation of the active, mature secretory product, CT, which is released by exocytosis at the apical surface of the NE cell.

  • HoloAPP levels are likely limiting at one or more sorting steps in the late secretory pathway, since activated sAPP α shedding is apparently accompanied by diminished generation of sAPP β [51].

  • SecB binds portions of the mature secretory protein [ 14 15 16 17 18 ] , and SecA would bind to the SecB-precursor complex by virtue of its ability to bind SecB [ 19 20 ] as well as the preprotein [ 21 22 23 ] . Thus, SecA-mediated targeting of the preprotein to translocase would occur.

  • More recent observations support an alternative mechanism of action for the PrlA/SecY and PrlG/SecE suppressors [ 8 12 ] . First, PrlA/G-mediated suppression does not exhibit allele specificity; all prlA and all prlG alleles that have been examined suppress all signal sequence mutations, implying that suppression is not due to a specific altered interaction that allows recognition of a mutant signal sequence [ 8 12 ] . Furthermore, all of the prlA and prlG alleles suppress complete deletions of the signal sequence, suggesting that an interaction between the signal sequence and the Prl suppressor is not necessary for suppression or even for export [ 5 8 13 ] . Based on these observations, it was proposed that the PrlA and PrlG suppressors do not function through altered interactions with signal sequences, but rather by loss of recognition [ 8 12 ] . The wild type SecE and SecY proteins are thought to function in concert to proofread the signal sequence of secretory proteins, rejecting defective precursors from the export pathway.


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