Words similar to scn
Example sentences for: scn
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As a consequence of a signal from the circadian clock, located in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus in mammals [ 1 ] , sleep is more likely to occur at certain times of the 24-h day than others, thereby determining the daily sleep-wake distribution [ 2 ] . Sleep is homeostatically regulated in the sense that sleep drive accumulates in the absence of sleep and decreases during sleep.
In addition, we have found (see below) that nocturnin is expressed in multiple brain regions including the suprachiasmatic nucleus (SCN), the site of the central circadian oscillator controlling behavioral rhythmicity [ 26].
Thus, in both nocturnal and diurnal species, per expression in the cortex is maximal in conjunction with the major waking episode [ 37 49 50 ] . Under conditions where the phase (methamphetamine administration, restricted feeding) or distribution (circadian splitting) of locomotor activity is altered, per expression in the cortex parallels the overt rhythm of wakefulness, whereas the circadian oscillation of per gene expression in the SCN remains unaffected [ 49 51 52 ] . Thus, in contrast to its role in the SCN, PER protein in the cortex is not a component of a self-sustaining circadian oscillator [ 53 ] . Instead, per expression in the cortex seems to the follow sleep-wake history, consistent with the hypothesis that it is related to homeostatic regulation of sleep.
Although the in situ hybridization data suggest low amplitude rhythmicity in these brain regions (including the SCN), we have not detected rhythmic expression in the brain comparable to the high amplitude rhythmicity detected in peripheral tissues.
Furthermore, muscimol inhibited dye-transfer between neurons in the SCN culture in a dose-dependent fashion, so that GABA might have reduced gap junction communication between SCN neurons via the GABAA receptor [ 14 ] . In that study they could not clarify how the activation of a GABAA receptor and subsequent increase in chloride conductance impact gap junctions.
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