Words similar to scn
Example sentences for: scn
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At the molecular level, per2 expression (but not that of per1 ) is rhythmic in the SCN of cry1,2 -/-mice under LD conditions.
Upon release into constant darkness cry1,2 -/-mice immediately become arrhythmic at the behavioral level [ 22 23 ] , at the level of SCN electrophysiology [ 28 ] , and at the cellular/molecular level [ 23 ] . Of the available mouse models for circadian dysfunction, only per1,2 double mutant mice [ 29 ] , bmal1 knockout mice [ 30 ] , and mice with an ablation of the SCN [ 31 ] show a similarly dramatic phenotype.
In addition, we have found (see below) that nocturnin is expressed in multiple brain regions including the suprachiasmatic nucleus (SCN), the site of the central circadian oscillator controlling behavioral rhythmicity [ 26].
Thus, in both nocturnal and diurnal species, per expression in the cortex is maximal in conjunction with the major waking episode [ 37 49 50 ] . Under conditions where the phase (methamphetamine administration, restricted feeding) or distribution (circadian splitting) of locomotor activity is altered, per expression in the cortex parallels the overt rhythm of wakefulness, whereas the circadian oscillation of per gene expression in the SCN remains unaffected [ 49 51 52 ] . Thus, in contrast to its role in the SCN, PER protein in the cortex is not a component of a self-sustaining circadian oscillator [ 53 ] . Instead, per expression in the cortex seems to the follow sleep-wake history, consistent with the hypothesis that it is related to homeostatic regulation of sleep.
As a consequence of a signal from the circadian clock, located in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus in mammals [ 1 ] , sleep is more likely to occur at certain times of the 24-h day than others, thereby determining the daily sleep-wake distribution [ 2 ] . Sleep is homeostatically regulated in the sense that sleep drive accumulates in the absence of sleep and decreases during sleep.
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