Words similar to scn
Example sentences for: scn
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Homeostatic and circadian mechanisms interact to determine the duration and quality of sleep and wakefulness [ 3 4 5 ] . Homeostatic regulation of sleep can still be observed in animals that lack circadian rhythms after lesioning of the SCN [ 6 7 8 9 ] , suggesting that circadian rhythms and sleep homeostasis are independent processes.
This indicated that the propagation of depolarization between SCN cells was inhibited by GABA A receptor activation.
In nocturnal rodents, lesioning the SCN results in more fragmented sleep, with lower EEG delta power, but leaving the daily sleep time unchanged [ 6 7 8 31 ] . Lesioning the SCN in a diurnal primate, the squirrel monkey, did result in an increase in NREMS time, but sleep was more fragmented, with a higher proportion of 'light' NREMS [ 5 ] ; i.e., with lower overall levels of EEG delta power.
Thus, in both nocturnal and diurnal species, per expression in the cortex is maximal in conjunction with the major waking episode [ 37 49 50 ] . Under conditions where the phase (methamphetamine administration, restricted feeding) or distribution (circadian splitting) of locomotor activity is altered, per expression in the cortex parallels the overt rhythm of wakefulness, whereas the circadian oscillation of per gene expression in the SCN remains unaffected [ 49 51 52 ] . Thus, in contrast to its role in the SCN, PER protein in the cortex is not a component of a self-sustaining circadian oscillator [ 53 ] . Instead, per expression in the cortex seems to the follow sleep-wake history, consistent with the hypothesis that it is related to homeostatic regulation of sleep.
As a matter of fact it was suggested that the gap junction coupling state between neurons in SCN is not static but dynamically regulated by the GABA A receptor system [ 14 ] . Also in vitro guinea-pig brain preparation prolonged seizure-like activity elicited using a brief application of bicuculline was abolished by the GJ channel blockers octanol and glycyrrhetinic acid as well as by intracellular acidification [ 16 ] .
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