Words similar to scn
Example sentences for: scn
How can you use “scn” in a sentence? Here are some example sentences to help you improve your vocabulary:
As a consequence of a signal from the circadian clock, located in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus in mammals [ 1 ] , sleep is more likely to occur at certain times of the 24-h day than others, thereby determining the daily sleep-wake distribution [ 2 ] . Sleep is homeostatically regulated in the sense that sleep drive accumulates in the absence of sleep and decreases during sleep.
Furthermore, muscimol inhibited dye-transfer between neurons in the SCN culture in a dose-dependent fashion, so that GABA might have reduced gap junction communication between SCN neurons via the GABAA receptor [ 14 ] . In that study they could not clarify how the activation of a GABAA receptor and subsequent increase in chloride conductance impact gap junctions.
Furthermore, the homeostatic response to sleep deprivation does not seem to be altered in SCN-lesioned rodents [ 6 7 8 ] . Thus, the sleep characteristics of cry1,2 -/-mice do not support the concept of cry1,2 -/-mice as simply a genetic model for ablation of the circadian clock in the SCN.
Homeostatic and circadian mechanisms interact to determine the duration and quality of sleep and wakefulness [ 3 4 5 ] . Homeostatic regulation of sleep can still be observed in animals that lack circadian rhythms after lesioning of the SCN [ 6 7 8 9 ] , suggesting that circadian rhythms and sleep homeostasis are independent processes.
Deletion of the cryptochromes disinhibits the transcriptional activation of CLOCK:BMAL1 and NPAS2:BMAL1 target genes, resulting in increased levels of their transcripts in the SCN, liver, and retina [ 20 23 25 ] . We assayed the expression in the brain of three genes that are known targets of cryptochrome mediated transcriptional inhibition: albumin D-binding protein ( dbp [ 26 ] ), period (per)1 , and per2 [ 20 23 27 ] , in the middle of the daily light period.
Loading...