Words similar to scn

Example sentences for: scn

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At the molecular level, per2 expression (but not that of per1 ) is rhythmic in the SCN of cry1,2 -/-mice under LD conditions.
As a matter of fact it was suggested that the gap junction coupling state between neurons in SCN is not static but dynamically regulated by the GABA A receptor system [ 14 ] . Also in vitro guinea-pig brain preparation prolonged seizure-like activity elicited using a brief application of bicuculline was abolished by the GJ channel blockers octanol and glycyrrhetinic acid as well as by intracellular acidification [ 16 ] .
Furthermore, muscimol inhibited dye-transfer between neurons in the SCN culture in a dose-dependent fashion, so that GABA might have reduced gap junction communication between SCN neurons via the GABAA receptor [ 14 ] . In that study they could not clarify how the activation of a GABAA receptor and subsequent increase in chloride conductance impact gap junctions.
These findings in cry1,2 -/-mice contrast with the findings of sleep studies in animals that are rendered arrhythmic by lesioning of the SCN.
Upon release into constant darkness cry1,2 -/-mice immediately become arrhythmic at the behavioral level [ 22 23 ] , at the level of SCN electrophysiology [ 28 ] , and at the cellular/molecular level [ 23 ] . Of the available mouse models for circadian dysfunction, only per1,2 double mutant mice [ 29 ] , bmal1 knockout mice [ 30 ] , and mice with an ablation of the SCN [ 31 ] show a similarly dramatic phenotype.