Words similar to scn
Example sentences for: scn
How can you use “scn” in a sentence? Here are some example sentences to help you improve your vocabulary:
These findings in cry1,2 -/-mice contrast with the findings of sleep studies in animals that are rendered arrhythmic by lesioning of the SCN.
As a consequence of a signal from the circadian clock, located in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus in mammals [ 1 ] , sleep is more likely to occur at certain times of the 24-h day than others, thereby determining the daily sleep-wake distribution [ 2 ] . Sleep is homeostatically regulated in the sense that sleep drive accumulates in the absence of sleep and decreases during sleep.
As a matter of fact it was suggested that the gap junction coupling state between neurons in SCN is not static but dynamically regulated by the GABA A receptor system [ 14 ] . Also in vitro guinea-pig brain preparation prolonged seizure-like activity elicited using a brief application of bicuculline was abolished by the GJ channel blockers octanol and glycyrrhetinic acid as well as by intracellular acidification [ 16 ] .
Deletion of the cryptochromes disinhibits the transcriptional activation of CLOCK:BMAL1 and NPAS2:BMAL1 target genes, resulting in increased levels of their transcripts in the SCN, liver, and retina [ 20 23 25 ] . We assayed the expression in the brain of three genes that are known targets of cryptochrome mediated transcriptional inhibition: albumin D-binding protein ( dbp [ 26 ] ), period (per)1 , and per2 [ 20 23 27 ] , in the middle of the daily light period.
Optical imaging of neural activity evoked by electrical stimulation in the cultured rat suprachiasmatic nucleus (SCN) revealed that the spread of depolarization was inhibited by gap junction blockers (halothane, octanol) but not by a blocker of voltage-depended Na +channels.
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