Words similar to scn
Example sentences for: scn
How can you use “scn” in a sentence? Here are some example sentences to help you improve your vocabulary:
Homeostatic and circadian mechanisms interact to determine the duration and quality of sleep and wakefulness [ 3 4 5 ] . Homeostatic regulation of sleep can still be observed in animals that lack circadian rhythms after lesioning of the SCN [ 6 7 8 9 ] , suggesting that circadian rhythms and sleep homeostasis are independent processes.
Apart from the present observations in sleep-deprived rats and mice, several other reports confirm that cortical levels of per expression in wild type animals are high at times when sleep drive is high, irrespective of the phase at which the circadian expression of per peaks in the SCN.
These findings in cry1,2 -/-mice contrast with the findings of sleep studies in animals that are rendered arrhythmic by lesioning of the SCN.
At the molecular level, per2 expression (but not that of per1 ) is rhythmic in the SCN of cry1,2 -/-mice under LD conditions.
Thus, in both nocturnal and diurnal species, per expression in the cortex is maximal in conjunction with the major waking episode [ 37 49 50 ] . Under conditions where the phase (methamphetamine administration, restricted feeding) or distribution (circadian splitting) of locomotor activity is altered, per expression in the cortex parallels the overt rhythm of wakefulness, whereas the circadian oscillation of per gene expression in the SCN remains unaffected [ 49 51 52 ] . Thus, in contrast to its role in the SCN, PER protein in the cortex is not a component of a self-sustaining circadian oscillator [ 53 ] . Instead, per expression in the cortex seems to the follow sleep-wake history, consistent with the hypothesis that it is related to homeostatic regulation of sleep.
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