Words similar to scn
Example sentences for: scn
How can you use “scn” in a sentence? Here are some example sentences to help you improve your vocabulary:
Apart from the present observations in sleep-deprived rats and mice, several other reports confirm that cortical levels of per expression in wild type animals are high at times when sleep drive is high, irrespective of the phase at which the circadian expression of per peaks in the SCN.
Upon release into constant darkness cry1,2 -/-mice immediately become arrhythmic at the behavioral level [ 22 23 ] , at the level of SCN electrophysiology [ 28 ] , and at the cellular/molecular level [ 23 ] . Of the available mouse models for circadian dysfunction, only per1,2 double mutant mice [ 29 ] , bmal1 knockout mice [ 30 ] , and mice with an ablation of the SCN [ 31 ] show a similarly dramatic phenotype.
As a consequence of a signal from the circadian clock, located in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus in mammals [ 1 ] , sleep is more likely to occur at certain times of the 24-h day than others, thereby determining the daily sleep-wake distribution [ 2 ] . Sleep is homeostatically regulated in the sense that sleep drive accumulates in the absence of sleep and decreases during sleep.
Homeostatic and circadian mechanisms interact to determine the duration and quality of sleep and wakefulness [ 3 4 5 ] . Homeostatic regulation of sleep can still be observed in animals that lack circadian rhythms after lesioning of the SCN [ 6 7 8 9 ] , suggesting that circadian rhythms and sleep homeostasis are independent processes.
These findings in cry1,2 -/-mice contrast with the findings of sleep studies in animals that are rendered arrhythmic by lesioning of the SCN.
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