Words similar to rxrα

Example sentences for: rxrα

How can you use “rxrα” in a sentence? Here are some example sentences to help you improve your vocabulary:

Thus, LC-PUFA can activate PPARα/RXRα, leading to displacement of HNF4α from PPRE; or be converted to CoA derivatives, which in turn can suppress HNF4α transcriptional activity.
In contrast, no significant change in TBP and TAF II 135 is seen in extracts from T-RA treated RXRα -/-RARγ -/-cells, in which the RARγ gene has also been disrupted [ 50, 51] and which are known to be refractory to T-RA induced differentiation (Fig.
F9 cells in which the retinoid X receptor α gene has been disrupted by homologous recombination (RXRα -/-cells) are impaired in their response to T-RA [ 49].
Again, the phenotype of these cells is not the same as that of the RXRα -/-RARγ -/-cells where none of these events take place.
Similarly, ligand-dependent targeted proteolysis of several nuclear receptors has been observed [ [ 39 40 41 42 ] ]. In the estrogen receptor, the RARα, and the RXRα, deletion of the α-helix H12 of the ligand binding domain which is essential for ligand-dependent activation stabilises these proteins showing that proteolysis and transactivation are intimately linked [ [ 42 43 44 ] ]. In the case of nuclear receptors, their targeted proteolysis in the presence of ligand may be a mechanism for attenuating the physiological response to the ligand.