Words similar to rxr
Example sentences for: rxr
How can you use “rxr” in a sentence? Here are some example sentences to help you improve your vocabulary:
To examine the effects of RXR ligands on CAR transactivation in a more functional context, the rexinoid LG1069 was combined with the CAR inverse agonist androstanol and the agonist TCPOBOP in a series of transient transfection studies using different response elements.
For example, it is possible that the inhibitory effect of LG1069 in the stable CAR expressing cell line is based on the sequestration of limiting amounts of RXR into ligand-dependent homodimers, as has been suggested in previous studies using primary hepatocytes [ 17 ] . However, similar effects were observed with the relatively large amounts of RXR used for the biochemical studies or with the transient transfections, which relied on cotransfected RXR.
A previously described HepG2 derivative stably expressing mouse CAR [ 16 ] was used to determine the effects of RXR agonists on CAR function in the context of native chromatin.
The results described here also suggest that rexinoids may have modulatory effects on xenobiotic responses, and that such effects may differ for different CAR/RXR target genes.
The βRARE-TK-Luc reporter plasmid with three copies of the DR-5 motif from the promoter of the mouse RARβ2 gene has been described previously, as has the CYP2B10-TK-Luc reporter with two copies of the DR-4 type elements from the promoter of the mouse CYP2B10 gene and the CYP3A4-TK-luc reporter with three copies of the ER-6 element from the human CYP3A4 promoter [ 16 ] . Expression vectors for full length mCAR and RXR proteins were as described [ 9 ] . The cdm8-mCARΔ8 deletion construct containing a deletion of the last 8 amino acids and the mutant with 2 helix 3 mutations (F171L, I174A) that block ligand binding and response have been described previously [ 16 ] , as has the cdm8-RXRΔ19 construct with a deletion of the last 19 amino acids [ 3 ] .
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