Example sentences for: rxr

How can you use “rxr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To examine the effects of RXR ligands on CAR transactivation in a more functional context, the rexinoid LG1069 was combined with the CAR inverse agonist androstanol and the agonist TCPOBOP in a series of transient transfection studies using different response elements.

  • Purified CAR and RXR proteins were produced in bacteria and preincubated overnight at 4°C alone or in combination, and in the presence or absence of 10 -5M androstanol, 10 -6M TCPOBOP, 10 -6M of 9 cis-RA, as appropriate.

  • RAR/RXR binding to nuclear receptor corepressors such as NCoR and SMRT in the absence of ligand inhibits activation of RA responsive genes [ 3 4 ] . Ligand binding displaces the repressors and recruits coactivator proteins such as CBP which have histone acetyltransferase activity [ 5 ] . Histone acetylation allows for chromatin unwinding and transcriptional initiation of target gene expression [ 6 ] .

  • Overall, these results significantly increase the potential complexity of the response of RXR heterodimers to RXR ligands and suggest a potential modulatory effect of rexinoids on xenobiotic responses.

  • The effects of specific RXR ligands on the CAR/RXR heterodimer have not been characterized, although high concentrations of both 9-cis-RA and all-trans retinoic acid have been reported to block PB induction of the CAR targets CYP2B1 and CYP2B2 in primary rat hepatocytes [ 17 ] . In addition, a recent report suggests that both compounds decrease TCPOBOP-dependent CAR transactivation [ 18 ] . In both cases, these effects were primarily attributed to sequestration of limiting amounts of RXR into ligand-dependent homodimers or heterodimers with other receptors.


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