Words similar to rxrs
Example sentences for: rxrs
How can you use “rxrs” in a sentence? Here are some example sentences to help you improve your vocabulary:
The effects of the vitamin A metabolite retinoic acid (RA) are mediated by two classes of ligand dependent transcription factors, the retinoic acid receptors (RAR) and the retinoid X receptors (RXR) [ 1 ] . The RARs are activated by all trans RA and 9-cis RA whereas the RXRs are activated by 9-cis RA only.
Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are nuclear transcription factors that mediate the action of retinoids [ 11 12 ] . We have demonstrated that in the rat, castration resulted in an increase in mRNAs for RAR α and γ in the prostate; such effects were prevented by T replacement [ 13 ] . We also demonstrated that the levels of mRNAs for RAR α and γ in non-tumorigenic rat epithelial cells (NRP152) were down-regulated, whereas those in tumorigenic cells (NRP154) were unaffected or up-regulated following T treatment [ 14 ] . In addition, RAR α was over-expressed in tumorigenic NRP154 cells.
Previous studies have demonstrated that posttranslational modifications of RARs and RXRs are critical to the biological activity of the receptors.
Each gene may express several different isoforms because of alternative splicing and differential promoter usage [ 2 ] . Both the RARs and RXRs contain functional domains for DNA and ligand binding, dimerization with other transcription factors, and transactivation of RA responsive promoters.
RARs and RXRs function as heterodimers that bind to response elements in the promoters of target genes to regulate RA dependent transcription.
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