Words similar to rsv-infected

Example sentences for: rsv-infected

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Biochemical reconstitution studies using purified recombinant actin in vitro and studies in RSV-infected cells ( ex vivo ) demonstrated that actin functions as a viral transcription factor in both monomeric (G) and filamentous (F) forms, whereas the filamentous form appeared to be particularly important for viral morphogenesis [ 10 ] . Subsequent studies showed that at saturating actin concentration, profilin stimulated viral transcription even further, whereas profilin by itself had no transcriptional activity in the absence of actin [ 11 ] . These results suggested that the interaction of profilin with actin may be important for optimal activity of the RSV transcriptase.
Because profilin stimulated RSV transcription in vitro [ 11 ] and associated with viral transcriptional proteins, N and P, the obvious next question was to ask how important profilin was for viral gene expression in the intact RSV-infected cell.
An extract of the RSV-infected A549 cells was first subjected to immunoprecipitation by anti-P antibody and the precipitated proteins probed in immunoblot with profilin antibody.
In contrast, stress fibers were completely absent in RSV-infected A549 cells (Fig.
Combining these findings, we propose that the activated RhoA utilizes profilin to bring about a net polymerization of actin in the RSV-infected cells (Fig.