Words similar to rsv
Example sentences for: rsv
How can you use “rsv” in a sentence? Here are some example sentences to help you improve your vocabulary:
Together, these data indicate that RSV infection of A549 epithelial cells induces chemokine expression with distinct kinetics suggesting the mechanism of RSV induction differs from that of proinflammatory cytokines.
NAC is an antioxidant thiol that raises the intracellular pool of glutathione the major redox regulating mechanism in the A549 epithelial cell line [ 45 ] . Interestingly, it has been reported that NAC can have differential effects on NF-κB binding activity suggesting only a subset of NF-κB binding complexes are redox sensitive [ 58 ] . Moreover, it has been shown that NAC inhibits Rel A/p50 heterodimers but not p50 homodimers and can inhibit NF-κB binding to only certain variant κB elements which presumably interact with distinct redox sensitive NF-κB binding complexes [ 59 ] . These observations are consistent with our findings that indicate NAC predominantly inhibits Rel A homodimers since that was the major NF-κB subunit induced by RSV infection of A549 cells.
Since our laboratory is interested in deciphering the temporal signaling pathways in host-RSV interaction and the role of RSV gene products in the process, we have sought potential alternatives to the cDNA-based approach that might allow us to study the effect of functional loss of a specific RSV gene product during the course of a standard virus infection in cell culture.
Thus, NAC preferentially inhibited chemokine expression induced by RSV, while DEX predominantly inhibited chemokine expression induced by TNFα.
Our findings suggest that RSV induction of chemokine gene expression involves a redox-sensitive NF-κB signaling mechanism that differs from that mediated by TNFα and involving predominantly the Rel A subunit of NF-κB.
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