Words similar to rip-tag

Example sentences for: rip-tag

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Another study suggested that liver endothelial cells can induce antigen-specific tolerance of CD8 +T cells [ 51 ] . Perhaps RIP-Tag tumor endothelium develops a similar capability to induce tolerance to extravasating CD4 +T cells, a capability disrupted by radiation.
Previous studies have shown that adoptively transferred tumor antigen-specific CD4 +T cells can be tolerized in the secondary lymphoid organs [ 9 34 ] , including the RIP-Tag2 model [ 30 ] . Radiation may kill or disable regulatory T cells [ 35 36 ] , or other bone marrow-derived tolerizing cells and prevent the induction of tolerance in adoptively transferred tumor-specific T cells [ 9 ] . Additionally, the high but sub-lethal dose of radiation used leads to significant lymphopenia [ 37 ] . The sudden reduction in lymphocyte number may create the spatial allowance in spleen and lymph nodes necessary for the homing, activation and expansion of he adoptively-transferred T cells.