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Example sentences for: ril-

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In our initial experiments we compared the inhibitory activity of rIL-1Ra to that of HIG-82-IL-1Ra +cells - a cell line engineered to constitutively express human IL-1Ra - when each was added to HSF cultures simultaneously with IL-1β.
IL-10, a cytokine produced by activated macrophages and Th2-type T cells, has crucial inhibitory effect against several Th-1 type immune responses, such as the antigen-presenting functions of monocytes and macrophages [ 52 53 ] . IL-10 may play an important role in preventing the induction of IBD, since animals deficient in IL-10 will develop colitis spontaneously, and low levels of IL-10 are positively correlated with recurrences of Crohn's disease [ 25 54 ] . However, unlike TNF-α based therapies, the administration of recombinant IL-10 (rIL-10) shows poor clinical efficacy.
Interestingly, following extended culture under static conditions, largely unremarkable differences in activity were observed between the constitutively produced tIL-1Ra and rIL-1Ra.
5, using these conditions the single dose of rIL-1Ra was unable to block the effects of persistent IL-1β production.
Using this rationale, we compared the effectiveness of rIL-1Ra and tIL-1Ra under conditions in which the concentration of each would be similar at the time of IL-1β stimulation.