Words similar to rdek

Example sentences for: rdek

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Quantitative assessment of rDEK binding to related DQ-and DR- Y-box sequences
Quantification of the apparent dissociation constant (K d[app] ) for rDEK binding to related class II MHC Y-box motifs validates the relative hierarchy of DEK binding activity described above, and further emphasizes the contribution of gene-specific Y-box polymorphisms to DEK binding activity.
The HLA-DQA1*0101 Y-box sequence does bind rDEK specifically, with unlabeled probe sequence competing successfully for binding (Fig.
5 × 10 4counts per minute) per 15 μl binding reaction and 5 μg of nuclear extract (except as noted) or <1 μg of rDEK.
We have previously shown that activation of promyeloid cells causes dephosphorylation of DEK and diminished DEK binding to the HIV-2 long terminal repeat [ 16 17 32 ] . In this study, we show that rDEK can bind to the DQA1 Y box, and that DEK in nuclear extracts participates in the DQA1 Y-box binding complex in vitro . Thus, we propose a model in which intracellular signaling modulates the ability of DEK to bind DNA, causing alteration of MHC class II transcription.