Words similar to rdek

Example sentences for: rdek

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Quantification of the apparent dissociation constant (K d[app] ) for rDEK binding to related class II MHC Y-box motifs validates the relative hierarchy of DEK binding activity described above, and further emphasizes the contribution of gene-specific Y-box polymorphisms to DEK binding activity.
Quantitative assessment of rDEK binding to related DQ-and DR- Y-box sequences
Further characterization of rDEK binding to the polymorphic DQA1*0501 Y-box sequence and to the consensus ( HLA-DRA ) Y-box sequence establishes a relative hierarchy of DEK binding activity (Fig.
5b, lanes 6-10), the unlabelled probe sequence competes less well than do any of the other Y-box sequences, suggesting that rDEK alone binds to this sequence nonspecifically and with low affinity.
Finally, DEK binds differentially to specific Y-box sequences found in HLA-DQA1(*0101 and *0501 alleles) and HLA-DRA , consistent with observations of DQA1 gene-specific cell-surface expression [ 36 ] and allele-specific promoter activity [ 33 ] . The specificity of rDEK binding to these and other, related Y-box sequences (including HLA-DQB and HLA-DRB alleles associated with the DR4 haplotype) may correlate with a predisposition to autoim-mune disease seen with certain HLA haplotypes.