Words similar to rii
Example sentences for: rii
How can you use “rii” in a sentence? Here are some example sentences to help you improve your vocabulary:
For PKA binding, it was thought for a long time that only RII subunits bind to AKAPs.
The presence of labeling at the NMJ is consistent with the prevalence of RII in neuronal tissue [ 27 ] . The lack of staining in the muscle fibers is in agreement with the report that RIIβ did not show significant hybridization with skeletal muscle [ 19 ] .
Monoclonal antibodies against recombinant human soluble TNF receptor RI (mAb225) and RII (mAb226) were purchased from R&D Systems, Inc. (Minneapolis, MN).
This putative association is strengthened by finding for the first time that targeting of RIα requires the AKAP binding surface [ 17 ] . Yotiao is another AKAP enriched at the NMJ, but appears to bind only RII [ 30 ] . PKA phosphorylates the nAChR when stimulated at the synapse by the neuropeptide CGRP and by adenosine from muscle responding to acetylcholine [reviewed by [ 31 ] ]. This phosphorylation may regulate the degradation of the nAChR [ 32 ] . Consistent with the action at the presynapse, it was shown that PKA facilitation of acetylcholine release is dependent on nerve endplate calcium concentration [ 33 ] . Based on our observation of colocalization with synaptophysin at presynaptic vesicles, RIα may be the isotype that influences this release of neurotransmitter.
However, a new class of AKAPs was discovered when two dual-specific AKAPs (D-AKAP1 and D-AKAP2) were cloned using a fusion protein of the RIα as the bait in a yeast two-hybrid screen [ 15 16 ] ). Therefore, the contrasted distribution pattern between RI and RII may in part be due to selective association with different compartmentalized pools of AKAPs.
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