Words similar to rii
Example sentences for: rii
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This putative association is strengthened by finding for the first time that targeting of RIα requires the AKAP binding surface [ 17 ] . Yotiao is another AKAP enriched at the NMJ, but appears to bind only RII [ 30 ] . PKA phosphorylates the nAChR when stimulated at the synapse by the neuropeptide CGRP and by adenosine from muscle responding to acetylcholine [reviewed by [ 31 ] ]. This phosphorylation may regulate the degradation of the nAChR [ 32 ] . Consistent with the action at the presynapse, it was shown that PKA facilitation of acetylcholine release is dependent on nerve endplate calcium concentration [ 33 ] . Based on our observation of colocalization with synaptophysin at presynaptic vesicles, RIα may be the isotype that influences this release of neurotransmitter.
For PKA binding, it was thought for a long time that only RII subunits bind to AKAPs.
However, a new class of AKAPs was discovered when two dual-specific AKAPs (D-AKAP1 and D-AKAP2) were cloned using a fusion protein of the RIα as the bait in a yeast two-hybrid screen [ 15 16 ] ). Therefore, the contrasted distribution pattern between RI and RII may in part be due to selective association with different compartmentalized pools of AKAPs.
Our work demonstrated that keloid fibroblasts had higher cellular levels of several members of the TGFβ1 pathway (TGFβ1-RII and ED-A fibronectin; also thrombospondin-1 [ 36 ] ). In addition TGFβ1 effects on apoptosis differed in non-PP vs.
For keloid fibroblasts, the size and granularity of the α-SMA expressing cells was similar to those expressing ED-A fibronectin rather than TGFβ1-RII (not shown, please, see additional file 2: Additional data #2.ppt).
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