Example sentences for: rett

How can you use “rett” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Mutations in MECP2, the gene that encodes the DNA binding protein MeCP2 (methyl-CpG binding protein 2), have been found in approximately 65-77% of Rett syndrome patients [ 7 8 9 10 ] . The functional consequence of MECP2 mutations resulting in Rett syndrome is loss of function.

  • Three genes with increased expression in mutant clones (MTAP44, MMP3 and NTN4) and two with decreased expression (CRIP1 and COMP) were quantitatively tested in multiple clonal cell strains from two Rett females (with MECP2 mutations 1155del32 and R106W) using RT-PCR.

  • Named after Andreas Rett who first recognized the disorder in 1966 [ 2 ] , the syndrome is characterized by a constellation of clinical findings that have resulted in the establishment of clinical criteria for the diagnosis [ 3 ] . Common clinical features include early normal development until approximately 6-18 months of age followed by a period of developmental stagnation and subsequent regression, usually by 3 years of life.

  • A different design was used for the microarray study of Rett syndrome LCLs.

  • To identify potential downstream targets of MeCP2 modulation, we have compared global gene expression patterns in four matched pairs of clonally derived mutant or wild-type MECP2-expressing fibroblast cell strains from girls with Rett syndrome, and in five wild-type and four mutant MeCP2-expressing lymphoblastoid cell lines, by hybridizing Affymetrix U95 (A-E) oligonucleotide microarrays.


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