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Example sentences for: rett
How can you use “rett” in a sentence? Here are some example sentences to help you improve your vocabulary:
Previously reported microarray studies of female Rett and unrelated control brain samples revealed expression changes that were interpreted as secondary to the disease process, such as increased expression of glial-specific genes and decreased expression of neuronal genes [ 25 ] . Therefore, when searching for the primary targets of MeCP2 modulation, it might be advantageous to study a tissue that is less obviously involved in the pathologic processes of the disease.
These features bare resemblances to mitochondrial degeneration in other neurodegenerative conditions, including Alzheimer's disease [ 79 ] , prion disease [ 80 ] , Rett syndrome [ 81 ] , excitotoxic neuronal death [ 70 ] and Mn ++superoxide dismutase (SOD2) deletion [ 82 ] . Although in none of these conditions are sufficiently detailed observations available for a comprehensive comparison, MVISE could play a role in other neurodegenerative disorders.
Our study design was intended to take advantage of the mosaic X chromosome inactivation in cell strains of Rett syndrome females.
Second, if the inter-clonal variation we detected by the quantitative RT-PCR study of 5 genes in 22 clones from two different Rett individuals were representative of a general feature of diploid fibroblast clones, it could have masked any consistent biologically meaningful expression changes.
Random X inactivation patterns are characteristic for Rett syndrome that is caused by heterozygosity for mutations in the X-linked locus MECP2.