Words similar to rett
Example sentences for: rett
How can you use “rett” in a sentence? Here are some example sentences to help you improve your vocabulary:
Much to our surprise, expression levels of 5 genes in 11 additional MeCP2-deficient and 11 additional MeCP2-positive clones from two Rett individuals, one with a missense and one with a truncating mutation, showed tremendous variation.
Four fibroblast strains from females with clinically diagnosed Rett syndrome were obtained from Coriell Cell Repositories.
Previously reported microarray studies of female Rett and unrelated control brain samples revealed expression changes that were interpreted as secondary to the disease process, such as increased expression of glial-specific genes and decreased expression of neuronal genes [ 25 ] . Therefore, when searching for the primary targets of MeCP2 modulation, it might be advantageous to study a tissue that is less obviously involved in the pathologic processes of the disease.
These features bare resemblances to mitochondrial degeneration in other neurodegenerative conditions, including Alzheimer's disease [ 79 ] , prion disease [ 80 ] , Rett syndrome [ 81 ] , excitotoxic neuronal death [ 70 ] and Mn ++superoxide dismutase (SOD2) deletion [ 82 ] . Although in none of these conditions are sufficiently detailed observations available for a comprehensive comparison, MVISE could play a role in other neurodegenerative disorders.
Clonal mutant and wild-type MECP2 expressing fibroblast cell strains were successfully established from four Rett females with different mutations, one missense in the MBD, one missense in the TRD and two frameshift mutations leading to premature stop codons.
Loading...