Words similar to retrovirus
Example sentences for: retrovirus
How can you use “retrovirus” in a sentence? Here are some example sentences to help you improve your vocabulary:
Hyal-1 is a candidate tumor suppressor [ 5 18 ] , although it enhances extravasation and metastasis of prostate cancer cells [ 3 ] . Also, mutations in Hyal-1 may contribute to the pathogenesis of a lysosomal disorder, mucopolysaccharidosis IX [ 19 ] . Hyal-2 is a lysosomal protein, which is active at low pH [ 20 ] . This protein is also known to be a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus [ 21 ] .
, transduction by retrovirus and selection for drug resistance) produces immortal cell lines with limited transformation phenotypes [ 4 5 ] . However, expression of Tag has profound effects on the cell cycle, significantly reducing cell doubling time and increasing saturation density [ 4 5 6 ] . These direct effects of Tag result from binding and inactivation of the retinoblastoma family proteins (p130, Rb, p107) and the tumor suppressor, p53 [ 7 8 9 ] . Tag is rate limiting for G 1 transit, and this effect (as well as saturation density and growth in soft agar) is Tag-dose dependent [ 3 10 11 12 ] . Since the cell lines in this study are capable of entering a quiescent state at saturation density [ 6 ] , one might expect that the levels of Tag would decrease at saturation and as cells progressively slow down as a function of cell density.
The N9 murine microglia cell line was a gift kindly provided by Dr. P. Ricciardi-Castagnoli [ 62 ] . This cell line has been used extensively as a model for microglia [ 63 64 65 ] . These cells were derived by immortalization of day 13 embryonic brain cultures with a retrovirus carrying an activated v-myc oncogene.
The orfs adjacent to cg4715 (two upstream and two downstream) appear to be non-homologous to retrovirus orfs (data not shown) suggesting that it may either be an insect gene or a remnant of an integrated retroelement.
This receptor has previously been shown to elevate intracellular Ca 2+and activate CamKII in a ligand-dependent manner [ 6 37 38 ] . C57mg cells stably transformed with Rfz-2/β 2 AR retrovirus or wt C57mg cells were treated overnight with propranolol, a β 2 AR antagonist, to maintain the chimeric receptors in an inactivated state.
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