Words similar to replicons

Example sentences for: replicons

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Previously we have reported the successful construction of several dengue virus replicons which replicate intracellularly without the pre-M and E proteins required to form infectious virions, including one replicon which can be expressed from transfected DNA [ 12 ] . Towards the goal of devising a "live" dual vaccine based on only non-structural dengue proteins and heterologous HIV material, we report here that these replicons can be harnessed to express heterologous genes, including HIV gp160 and gp120.
Ideally, to serve as dual vaccines against dengue as well as against other pathogens, the replicons should express the dengue NS1 protein [ 29 30 31 32 ] . So far, attempts to visualize NS1 production by Western blots have failed, presumably because of the low transfection efficiencies.
Finally, by eliciting an immune reaction against the dengue non-structural proteins remaining in replicons, dengue virus replicons may induce a protective immunity against dengue which would not predispose vaccinated individuals to DHF.
Expression of virus & replicons in cells
More work needs to be done on determining the ability of dengue replicons to express other potential immunogens, including HIV-1 gag, tat (reviewed in 41) and env genes with deleted hypervariable regions [see [ 42 ] ]. Animal studies in our lab are currently being initiated to determine the nature of the immune response such vectors can induce in mice and these studies will presumably need to be extended to primates.