Words similar to recombinase
Example sentences for: recombinase
How can you use “recombinase” in a sentence? Here are some example sentences to help you improve your vocabulary:
Similar Cre reporter strains have been produced using different promoters to express lacZ [ [ 6 7 8 9 ] ], Another variation on this theme has been the development of the Z/AP reporter strain, which switches from lacZ to alkaline phosphatase expression upon exposure to Cre recombinase activity [ 10].
Furthermore, by using modified forms of Cre whose recombinase activity is inducible, one can use these reporter mice to perform detailed analysis on the lineage of cells at different time points during development.
Importantly, the pgk promoter of this cassette is flanked by loxP elements so that the promoter can easily be removed using Cre recombinase.
TCR, T cell receptor; MHC, major histocompatibility complex; H-2, murine MHC locus; Tag, SV40 T antigen; RIP, rat insulin promoter; RAG, recombinase activating gene.
Our finding that KRC binds to the RSS as well as the κB motif may also provide a link between transcription and recombination in the context of the accessibility model [ 58 59 ] . Enhancer or promoter elements are important for the recombination process in cell lines and animal models [ 60 ] . Similarly, expression of transcription factors, in conjunction with the recombination activating genes, has been shown to induce V(D)J recombination in non-lymphoid tissues by rendering RSS accessible to the recombinase [ 61 ] . The κB motif, first found in the Igκ light chain [ 62 ] , and later in the TCR β2 locus [ 31 ] , has been shown to promote V(D)J recombination by modulating locus accessibility [ 63 ] . In addition to influencing recombination by binding of RSS, KRC binding of the κB motif may modulate accessibility and transcription of target loci.
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