Example sentences for: raf

How can you use “raf” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This MAPK pathway encompasses a cascade of phosphorylation events involving three key kinases, namely Raf, MEK (MAP kinase kinase) and ERK (MAP kinase).

  • 14); no change was seen in activated c-Raf levels between control and SN50-treated explants.

  • That is, we then subjected those transcripts with altered expression in each group (cell cycle, apoptosis, Ras/Raf, TGF-β family) previously shown in Figures 7and 8 to be relatively important in defining the SN50 SMG phenotype to further PNN analysis.

  • The latter is consistent with the demonstration that c-Raf function is not mediated by the MAPK/ERK cascade [ 59 ] . Moreover, although we find an increase in total Raf protein (Table 2), no increase in activated c-Raf is found; we also see a 2-fold increase in activated Caspase 3 but no change in total Caspase 3 protein.

  • A common intermediate pathway initiating from receptors to the nucleus is the Ras/Raf/MEK/ERK (MAPK) cascade, which can result in the phosphorylation and activation of additional downstream kinases and transcription factors such as p90Rsk, CREB, Elk, and Egr-1 [ 55 56 ] . Therefore, it is intriguing that Tat expressing cells show down-regulation of MAPK components (Table 3, Figure 3Band 3C), essential mediators between receptors and nuclear transcription factors.


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